Evidence map›Paper›PMID 38717997›Full record

ArticlePloS one2024

Effect of an eight-week high-intensity interval training programme on circulating sphingolipid levels in middle-aged adults at elevated cardiometabolic risk (SphingoFIT)-Protocol for a randomised controlled exercise trial.

Justin Carrard, Manuel Hofer, Luisa Prechtl, Eva Fleischlin, Manuel Huber, Hector Gallart-Ayala, Tony Teav, Denis Infanger, Christoph Höchsmann, Karsten Koehler and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06024291 (Reducing Circulating Sphingolipid Levels to Optimise Cardiometabolic Health - The SphingoFIT Randomised Controlled Exercise Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06024291 nacompletednot on this map

Reducing Circulating Sphingolipid Levels to Optimise Cardiometabolic Health - The SphingoFIT Randomised Controlled Exercise Trial

TypeinterventionalSponsorUniversity of BaselRan2023 to 2025Enrolled88ConditionsOverweight and Obesity, Dyslipidemias, Blood Pressure, Cardiovascular DiseasesArms8-week HIIT programme, Physical activity recommendation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Justin CarrardDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.ORCID 0000-0002-2380-105X
Manuel HoferDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Luisa PrechtlDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Eva FleischlinDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Manuel HuberDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Hector Gallart-AyalaMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Tony TeavMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Denis InfangerDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.ORCID 0000-0001-9028-7110
Christoph HöchsmannDepartment of Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Karsten KoehlerDepartment of Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Timo HinrichsDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Henner HanssenDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.ORCID 0000-0001-5501-4205
Julijana IvanisevicMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Arno Schmidt-TrucksässDivision of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEvidence indicates that sphingolipid accumulation drives complex molecular alterations promoting cardiometabolic diseases. Clinically, it was shown that sphingolipids predict cardiometabolic risk independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, little is known about therapeutic modalities to lower sphingolipid levels. Exercise, a powerful means to prevent and treat cardiometabolic diseases, is a promising modality to mitigate sphingolipid levels in a cost-effective, safe, and patient-empowering manner.

methodsThis randomised controlled trial will explore whether and to what extent an 8-week fitness-enhancing training programme can lower serum sphingolipid levels of middle-aged adults at elevated cardiometabolic risk (n = 98, 50% females). The exercise intervention will consist of supervised high-intensity interval training (three sessions weekly), while the control group will receive physical activity counselling based on current guidelines. Blood will be sampled early in the morning in a fasted state before and after the 8-week programme. Participants will be provided with individualised, pre-packaged meals for the two days preceding blood sampling to minimise potential confounding. An 'omic-scale sphingolipid profiling, using high-coverage reversed-phase liquid chromatography coupled to tandem mass spectrometry, will be applied to capture the circulating sphingolipidome. Maximal cardiopulmonary exercise tests will be performed before and after the 8-week programme to assess patient fitness changes. Cholesterol, triglycerides, glycated haemoglobin, the homeostatic model assessment for insulin resistance, static retinal vessel analysis, flow-mediated dilatation, and strain analysis of the heart cavities will also be assessed pre- and post-intervention. This study shall inform whether and to what extent exercise can be used as an evidence-based treatment to lower circulating sphingolipid levels.

trial registrationThe trial was registered on www.clinicaltrials.gov (NCT06024291) on August 28, 2023.

Indexed as

High-Intensity Interval TrainingSphingolipidsAdultBiomarkersCardiometabolic Risk FactorsCardiovascular DiseasesExerciseExercise TherapyFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicBiomarkersSphingolipids

Identifiers

PMID38717997
PMCPMC11078397

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.