Evidence map›Paper›PMID 38719807›Full record

ArticleCell death discovery2024

Neutrophil diversity is associated with T-cell immunity and clinical relevance in patients with thyroid cancer.

Seong Eun Lee, Bon Seok Koo, Pureum Sun, Shinae Yi, Na Rae Choi, Jiyeon Yoon, Seon-Young Kim, Seon-Kyu Kim, Seongyeol Park, Aliya Lakhani and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Seong Eun Lee *Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0001-5793-3774
Bon Seok Koo *Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital & College of Medicine, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-5928-0006
Pureum SunResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Shinae YiResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Na Rae ChoiResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Jiyeon YoonResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.ORCID http://orcid.org/0009-0000-3721-4529
Seon-Young KimKorea Research Institute of Bioscience and Biotechnology, Deajeon, Republic of Korea.ORCID http://orcid.org/0000-0002-1030-7730
Seon-Kyu KimKorea Research Institute of Bioscience and Biotechnology, Deajeon, Republic of Korea.ORCID http://orcid.org/0000-0002-4176-5187
Seongyeol ParkStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Aliya LakhaniDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Samantha O'KeeffeDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Junyoung O ParkDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0001-9869-8993
Da Hyun KangResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. ibelieveu113@naver.com.ORCID http://orcid.org/0000-0002-3495-0931
Yea Eun KangResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. yeeuni2200@gmail.com.ORCID http://orcid.org/0000-0002-2012-3716

Funding

Korea Health Industry Development Institute (KHIDI) HR20C0025Korea Health Industry Development Institute (KHIDI) HR22C1734Korea Institute for Advancement of Technology (KIAT) P0009796National Research Foundation of Korea (NRF) 2021R1C1C1011183National Research Foundation of Korea (NRF) 2022R1C1C1007301National Research Foundation of Korea (NRF) 2022R1I1A1A01071876
6 · The paper itself

Abstract

Neutrophil heterogeneity is involved in autoimmune diseases, sepsis, and several cancers. However, the link between neutrophil heterogeneity and T-cell immunity in thyroid cancer is incompletely understood. We investigated the circulating neutrophil heterogeneity in 3 undifferentiated thyroid cancer (UTC), 14 differentiated thyroid cancer (DTC) (4 Stage IV, 10 Stage I-II), and healthy controls (n = 10) by transcriptomic data and cytometry. Participants with UTC had a significantly higher proportion of immature high-density neutrophils (HDN) and lower proportion of mature HDN in peripheral blood compared to DTC. The proportion of circulating PD-L1

Identifiers

PMID38719807
PMCPMC11078953

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.