ArticleNature2024
Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Augmentation Therapy With Serotonin 5-HTNeuropsychopharmacology reports · 2025Pooled it
- Impact of psilocybin on cognitive function: A systematic review.Psychiatry and clinical neurosciences · 2024Pooled it
- Prior trauma shapes the effects of psilocybin on stress sensitization in mice.Neuroscience letters · 2026Article
- Ibogalogs reduce acute and chronic headache-like behaviours in rodents by different co-modulatory mechanisms involving 5-HTResearch square · 2026Article
- Inhalable Psychedelic 5-MeO-DMT Shows Promise in Treatment-Resistant Depression.Journal of medicinal chemistry · 2026Article
- Role of β-Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs.ACS chemical neuroscience · 2026Article
- Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-ACS chemical neuroscience · 2026Article
- Article
- Structural and dynamic studies uncover a distinct allosteric modulatory site at the µ-opioid receptor.Nature communications · 2026Article
- Ibogalogs induce antiseizure activity in rodents by a mechanism involving 5-HTBiochemical pharmacology · 2026Article
- Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice.BMC neuroscience · 2026Article
- The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects.Molecular psychiatry · 2026Article
- Psychedelics elicit their effects by 5-HTNature · 2026Article
- Deciphering Ibogaine's Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses.Journal of the American Chemical Society · 2026Article
- Psychedelic Drugs Rediscovered-In Silico Study of Potential Fetal Exposure to Analogues of Psychedelic Drugs During Pregnancy.Molecules (Basel, Switzerland) · 2026Article
- Restoring oscillatory dynamics in Alzheimer's disease: A laminar whole-brain model of serotonergic psychedelic effects.Network neuroscience (Cambridge, Mass.) · 2026Article
- Biased Signaling in Psychedelic Action.Annual review of pharmacology and toxicology · 2026Review
- Mind the gap! Addressing unresolved aspects of abuse potential evaluation and scheduling of classic and novel psychedelic drugs.Journal of psychopharmacology (Oxford, England) · 2026Review
- The ABCs of psychedelics: a preclinical roadmap for drug discovery.Trends in pharmacological sciences · 2025Review
- A Concise and Divergent Approach to the Naturally Occurring Tetracyclic Clavine Alkaloids (+)-Lysergol, (+)-Lysergine, and (+)-Isolysergine.The Journal of organic chemistry · 2025Article
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Audrey L Warren *Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1538-8648
David Lankri *Department of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0002-1210-5673
Michael J CunninghamDepartment of Chemistry, Columbia University, New York, NY, USA.
Inis C SerranoDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0002-3588-821X
Lyonna F PariseDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7527-8977
Andrew C KruegelDepartment of Chemistry, Columbia University, New York, NY, USA.
Priscilla DugganDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0002-9728-282X
Gregory ZilbergZuckerman Institute of Mind, Brain, Behavior, Columbia University, New York, NY, USA.
Michael J CapperDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0102-6993
Vaclav HavelDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0002-6911-4669
Scott J RussoDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6470-1805
Dalibor SamesDepartment of Chemistry, Columbia University, New York, NY, USA. ds584@columbia.edu.ORCID 0000-0001-6911-2260
Daniel WackerDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. daniel.wacker@mssm.edu.ORCID 0000-0003-4951-7230
Funding
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI KIEFT, JEFFREY S · 2012 to 2021
$14.7MROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2MTeaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2MChemistry and Pharmacology of Iboga AlkaloidsR01DA050613 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DALIBOR SAMES · 2020 to 2026
$4.1MNeural Circuit Mechanisms of Stress-Impaired Social RewardR01MH127820 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2021 to 2025
$3.5MStructural Studies and Drug Discovery Illuminate Serotonin PharmacologyR35GM133504 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Daniel Wacker · 2019 to 2026
$3.4MTraining Program in Substance Use DisordersT32DA053558 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2021 to 2026
$2.6MSex Differences in Neural Circuit Mechanisms of AggressionR01MH133299 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2023 to 2026
$2.6MAcquisition of Detector for JEOL 3200 FSC Electron MicroscopeS10OD019994 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI CARRAGHER, BRIDGET OLIVIA · 2015 to 2015
$600kCryoprobe Upgrade of a 500 MHz NMR SpectrometerS10OD026749 · OD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DECATUR, JOHN D · 2019 to 2019
$376kStructural studies of psychedelic activity at the serotonin receptor 5-HT1AF31MH132317 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WARREN, AUDREY LOUISE · 2022 to 2023
$85kNIDA NIH HHS R01 DA050613NIDA NIH HHS T32 DA053558NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R35 GM133504NIGMS NIH HHS T32 GM062754NIGMS NIH HHS U24 GM129539NIH HHS S10 OD019994NIH HHS S10 OD026749NIMH NIH HHS F31 MH132317NIMH NIH HHS R01 MH104559NIMH NIH HHS R01 MH127820NIMH NIH HHS R01 MH133299
Abstract
Psychedelic substances such as lysergic acid diethylamide (LSD) and psilocybin show potential for the treatment of various neuropsychiatric disorders
Indexed as
5-MethoxytryptamineAnti-Anxiety AgentsAntidepressive AgentsMethoxydimethyltryptaminesReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AAnimalsCryoelectron MicroscopyHallucinogensHumansLysergic Acid DiethylamideMaleMiceModels, MolecularSerotonin Receptor AgonistsStructure-Activity Relationship5-MethoxytryptamineAnti-Anxiety AgentsAntidepressive AgentsHallucinogensLysergic Acid DiethylamideMethoxydimethyltryptaminesReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2ASerotonin Receptor Agonists
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.