Evidence map›Paper›PMID 38720111›Full record

ArticlePediatric nephrology (Berlin, Germany)2024

Dyslipidemia in children with chronic kidney disease-findings from the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study.

Francesca Mencarelli, Karolis Azukaitis, Marietta Kirchner, Aysun Bayazit, Ali Duzova, Nur Canpolat, Ipek Kaplan Bulut, Lukasz Obrycki, Bruno Ranchin, Rukshana Shroff and 12 more

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Francesca MencarelliPediatric Nephrology Unit, Department of Pediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Karolis AzukaitisClinic of Pediatrics, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Marietta KirchnerInstitute for Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Aysun BayazitDepartment of Pediatric Nephrology, Cukurova University, Adana, Turkey.
Ali DuzovaDivision of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Nur CanpolatDepartment of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Ipek Kaplan BulutDivision of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
Lukasz ObryckiDepartment of Nephrology and Arterial Hypertension, Children's Memorial Health Institute, Warsaw, Poland.
Bruno RanchinPediatric Nephrology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Université de Lyon, Lyon, France.
Rukshana ShroffUCL Great Ormond Street Institute of Child Health, London, UK.
Salim CaliskanDivision of Pediatric Nephrology, Göztepe Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
Cengiz CandanDivision of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
Alev YilmazFaculty of Medicine, Istanbul University, Istanbul, Turkey.
Zeynep Birsin ÖzcakarDivision of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Ankara University, Ankara, Turkey.
Harika HalpayDepartment of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Aysel KiyakDivision of Pediatric Nephrology, Department of Pediatrics, Bakirkoy Children's Hospital, Istanbul, Turkey.
Hakan ErdoganDivision of Pediatric Nephrology, Faculty of Medicine, Uludağ University, Bursa, Turkey.
Jutta GellermannDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité University Hospital, Berlin, Germany.
Ayse BalatDepartment of Pediatric Nephrology, Gaziantep University, Gaziantep, Turkey.
Anette MelkDepartment of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Franz SchaeferPediatric Nephrology Division, Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany.
Uwe QuerfeldDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité University Hospital, Berlin, Germany. uwe.querfeld@charite.de.ORCID http://orcid.org/0000-0001-6783-3822

Funding

Bundesministerium für Wissenschaft, Forschung und Wirtschaft 01EO0802
6 · The paper itself

Abstract

backgroundDyslipidemia is an important and modifiable risk factor for CVD in children with CKD.

methodsIn a cross-sectional study of baseline serum lipid levels in a large prospective cohort study of children with stage 3-5 (predialysis) CKD, frequencies of abnormal lipid levels and types of dyslipidemia were analyzed in the entire cohort and in subpopulations defined by fasting status or by the presence of nephrotic range proteinuria. Associated clinical and laboratory characteristics were determined by multivariable linear regression analysis.

resultsA total of 681 patients aged 12.2 ± 3.3 years with a mean eGFR of 26.9 ± 11.6 ml/min/1.73 m

conclusionsDyslipidemia involving all lipid fractions, but mainly TG, is present in the majority of patients with CKD irrespective of CKD stage or fasting status and is significantly associated with other cardiovascular risk factors.

Indexed as

Cardiovascular DiseasesDyslipidemiasGlomerular Filtration RateRenal Insufficiency, ChronicAdolescentChildComorbidityCross-Sectional StudiesFemaleHumansLipidsMaleProspective StudiesProteinuriaRisk FactorsTriglyceridesLipidsTriglyceridesAlbuminuriaChildrenChronic kidney diseaseDyslipidemiaFasting

Identifiers

PMID38720111
PMCPMC11272819

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.