Evidence map›Paper›PMID 38721498›Full record

ArticleInternational journal of ophthalmology2024

Yu Qian, Ying Xiao, Qiu-Rong Lin, Zhao-Yu Xiang, Li-Pu Cui, Jia-Qi Sun, Si-Cong Li, Xin-Ran Qin, Hai-Dong Zou, Chen-Hao Yang and 1 more

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In one paragraph

Article in International journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu QianDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.
Ying XiaoDepartment of Ophthalmology, Children's Hospital of Fudan University, Shanghai 201102, China.
Qiu-Rong LinShanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai 200040, China.
Zhao-Yu XiangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.
Li-Pu CuiDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.
Jia-Qi SunDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.
Si-Cong LiDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.
Xin-Ran QinDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.
Hai-Dong ZouDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.
Chen-Hao YangDepartment of Ophthalmology, Children's Hospital of Fudan University, Shanghai 201102, China.
Pei-Yao JinDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai First People's Hospital, Shanghai 200080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify the differential methylation sites (DMS) and their according genes associated with diabetic retinopathy (DR) development in type 1 diabetes (T1DM) children.

methodsThis study consists of two surveys. A total of 40 T1DM children was included in the first survey. Because no participant has DR, retina thinning was used as a surrogate indicator for DR. The lowest 25% participants with the thinnest macular retinal thickness were included into the case group, and the others were controls. The DNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay, and compared between the case and control groups. Four DMS with a potential role in diabetes were identified. The second survey included 27 T1DM children, among which four had DR. The methylation patterns of the four DMS identified by 850K were compared between participants with and without DR by pyrosequencing.

resultsIn the first survey, the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls (|Δβ|>0.1 and Adj.

conclusionThe hypermethylation of the

Indexed as

850K arraychildrendiabetic retinopathyDNA methylationpyrosequencingtype 1 diabetes

Identifiers

PMID38721498
PMCPMC11074160

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.