SynthesisHypertension (Dallas, Tex. : 1979)2024
Influence of Blood Pressure Reduction on Pulse Wave Velocity in Primary Hypertension: A Meta-Analysis and Comparison With an Acute Modulation of Transmural Pressure.
Synthesis in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Disparities in Blood Pressure Measurement.Current hypertension reports · 2026Review
- Clinical Relevance and Potential Applications of Brachial-Ankle Pulse Wave Velocity: Current Evidence and Future Perspectives.Journal of clinical medicine · 2026Review
- Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.Annals of biomedical engineering · 2026Article
- Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort.Pediatric nephrology (Berlin, Germany) · 2026Article
- Article
- Effects of Pre-Dialysis Fluid Overload, Intradialytic Relative Blood Volume Levels, and Cumulative Ultrafiltration Volume on Pulse Wave-Derived Features during Hemodialysis: Results from a Longitudinal Cohort Study.Kidney & blood pressure research · 2026Article
- Clinical effects of Yiqi-Yangyin-Huoxue granules in the management of type 2 diabetes mellitus and early vascular aging: a randomized, double-blind, placebo-controlled trial protocol.Frontiers in medicine · 2026Article
- Pulse Wave Velocity Progression Determinants: No Significant Association with Novel Lipids Parameter.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Association Between Pulse Wave Velocity and Cerebral Small Vessel Disease: A Scoping Review.Cureus · 2025Review
- Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice.Cardiovascular diabetology · 2025Article
- Association of estimated pulse wave velocity with all-cause mortality and cardiovascular mortality in obstructive sleep apnea patients: results from NHANES.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundIncreased arterial stiffness and pulse wave velocity (PWV) of the aorta and large arteries impose adverse hemodynamic effects on the heart and other organs. Antihypertensive treatment reduces PWV, but it is unknown whether this results from an unloading of stiffer elements in the arterial wall or is due to an alternate functional or structural change that might differ according to class of antihypertensive drug.
methodsWe performed a systematic review and meta-analysis of the effects of different antihypertensive drug classes and duration of treatment on PWV with and without adjustment for change in mean arterial blood pressure (BP; study 1) and compared this to the change in PWV after an acute change in transmural pressure, simulating an acute change in BP (study 2).
resultsA total of 83 studies involving 6200 subjects were identified. For all drug classes combined, the reduction of PWV was 0.65 (95% CI, 0.46-0.83) m/s per 10 mm Hg reduction in mean arterial BP, a change similar to that induced by an acute change in transmural pressure in a group of hypertensive subjects. When adjusted for change in mean arterial BP, the reduction in PWV after treatment with beta-blockers or diuretics was less than that after treatment with angiotensin-converting enzyme inhibitors/angiotensin receptor antagonists or calcium channel antagonists.
conclusionsReduction in PWV after antihypertensive treatment is largely explained by the reduction in BP, but there are some BP-independent effects. These might increase over time and contribute to better outcomes over the long term, but this remains to be demonstrated in long-term clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.