Evidence map›Paper›PMID 38722530›Full record

ArticleImmunologic research2024

Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis.

Ziliang Yu, Peipei Li, Dagong Gao, Yalong Hu, Fei Xia, Lei Liu, Jian Liu, Wei Liu, Haiping Zhang

Abstract read
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In one paragraph

Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziliang YuDepartment of Orthopaedics, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No.666 Shengli Road, Nantong, 226000, Jiangsu, China.
Peipei LiDepartment of Operating Room, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, Nantong, 226000, Jiangsu, China.
Dagong GaoDepartment of Orthopaedics, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No.666 Shengli Road, Nantong, 226000, Jiangsu, China.
Yalong HuDepartment of Orthopaedics, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Nantong, 226000, Jiangsu, China.
Fei XiaDepartment of Orthopaedics, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No.666 Shengli Road, Nantong, 226000, Jiangsu, China.
Lei LiuDepartment of Orthopaedics, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No.666 Shengli Road, Nantong, 226000, Jiangsu, China.
Jian LiuDepartment of Orthopaedics, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No.666 Shengli Road, Nantong, 226000, Jiangsu, China.
Wei LiuDepartment of Orthopaedics, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No.666 Shengli Road, Nantong, 226000, Jiangsu, China. liuweidr@yeah.net.
Haiping ZhangDepartment of Orthopaedics, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No.666 Shengli Road, Nantong, 226000, Jiangsu, China. zhanghaipingx@163.com.

Funding

Nantong First People's Hospital Provincial and Ministerial Level High-level Science and Technology Project Cultivation Fund YPYJJYB23002Nantong Youth Medical Expert Project JC22022029
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and cartilage and bone destruction. Lysine-specific demethylase 1 (LSD1), an enzyme involved in transcriptional regulation, has an unclear role in synovial inflammation, fibroblast-like synoviocytes migration, and invasion during RA pathogenesis. In this study, we observed increased LSD1 expression in RA synovial tissues and in TNF-α-stimulated MH7A cells. SP2509, an LSD1 antagonist, directly reduced LSD1 expression and reversed the elevated levels of proteins associated with inflammation, apoptosis, proliferation, and autophagy induced by TNF-α. Furthermore, SP2509 inhibited the migratory capacity of MH7A cells, which was enhanced by TNF-α. In CIA models, SP2509 treatment ameliorated RA development, reducing the expression of pro-inflammatory cytokines and alleviating joint pathological symptoms. These findings underscore the significance of LSD1 in RA and propose the therapeutic potential of SP2509.

Indexed as

Arthritis, RheumatoidHistone DemethylasesAnimalsApoptosisArthritis, ExperimentalAutophagyCell LineCell MovementCell ProliferationCytokinesDisease ProgressionHumansMaleMiceSynovial MembraneSynoviocytesCytokinesHistone DemethylasesKDM1A protein, humanTumor Necrosis Factor-alphaLSD1MH7ARheumatoid arthritisSP2509

Identifiers

PMID38722530

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.