Evidence map›Paper›PMID 38724014›Full record

ArticleACS infectious diseases2024

Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with

Albertina Scattolini, Konstantinos Grammatoglou, Anna Nikitjuka, Aigars Jirgensons, María Cecilia Mansilla, Björn Windshügel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Albertina ScattoliniInstituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas, Ocampo y Esmeralda, S2000FHQ Rosario, Argentina.
Konstantinos GrammatoglouLatvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.
Anna NikitjukaLatvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.
Aigars JirgensonsLatvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.ORCID 0000-0002-8937-8792
María Cecilia MansillaInstituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas, Ocampo y Esmeralda, S2000FHQ Rosario, Argentina.ORCID 0000-0002-1444-8661
Björn WindshügelFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, 22525 Hamburg, Germany.ORCID 0000-0002-4835-3134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoic acid (LA) is an essential cofactor in prokaryotic and eukaryotic organisms, required for the function of several multienzyme complexes such as oxoacid dehydrogenases. Prokaryotes either synthesize LA or salvage it from the environment. The salvage pathway in

Indexed as

Anti-Bacterial AgentsStaphylococcus aureusThioctic AcidAnimalsBacterial ProteinsCaenorhabditis elegansPeptide SynthasesStaphylococcal InfectionsVirulenceAnti-Bacterial AgentsBacterial Proteinslipoate-protein ligasePeptide SynthasesThioctic Acidinfection modellipoic acidLplA2salvage pathwayStaphylococcus aureusvirtual screening

Identifiers

PMID38724014
PMCPMC11184557

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.