Evidence map›Paper›PMID 38725382›Full record

ArticleVisual neuroscience2024

Chemically induced cone degeneration in the 13-lined ground squirrel.

Hannah M Follett, Emma Warr, Jenna Grieshop, Ching Tzu Yu, Mina Gaffney, Owen R Bowie, Jong Won Lee, Sergey Tarima, Dana K Merriman, Joseph Carroll

Abstract read
In one paragraph

Article in Visual neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hannah M FollettDepartment of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-7221-2286
Emma WarrDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jenna GrieshopDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Ching Tzu YuDepartment of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Mina GaffneyJoint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Owen R BowieSchool of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jong Won LeeDivision of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Sergey TarimaDivision of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Dana K MerrimanDepartment of Biology, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, USA.
Joseph CarrollDepartment of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-8640-1029

Funding

Developing Cone-Dominant Retinal Disease Models as a Resource for Translational Vision ResearchU24EY029891 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI CARROLL, JOSEPH, DUNCAN, JACQUE LYNNE · 2018 to 2022
$6.6M
Platform Technologies for Microscopic Retinal Imaging: Development & TranslationU01EY025477 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$4.4M
Rresearch Training Program in Vision ScienceT32EY014537 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Elena V Semina · 2002 to 2026
$4.2M
VISION RES LAB: HERPETIC KERATIC, CORE PIGMENT GENES, RETINITIS PIGMENTOSAC06RR016511 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI DUNN, MICHAEL J · 2002 to 2002
$1.4M
Foundation Fighting Blindness FFB PPA-0641-0718-UCSFNCRR NIH HHS C06 RR016511NCRR NIH HHS C06RR016511NEI NIH HHS T32 EY014537NEI NIH HHS U01 EY025477NEI NIH HHS U01EY025477NEI NIH HHS U24 EY029891NEI NIH HHS U24EY029891
6 · The paper itself

Abstract

Animal models of retinal degeneration are critical for understanding disease and testing potential therapies. Inducing degeneration commonly involves the administration of chemicals that kill photoreceptors by disrupting metabolic pathways, signaling pathways, or protein synthesis. While chemically induced degeneration has been demonstrated in a variety of animals (mice, rats, rabbits, felines, 13-lined ground squirrels (13-LGS), pigs, chicks), few studies have used noninvasive high-resolution retinal imaging to monitor the

Indexed as

Retinal Cone Photoreceptor CellsRetinal DegenerationSciuridaeTomography, Optical CoherenceAnimalsDisease Models, AnimalFemaleIntravitreal InjectionsMaleNitroprussideOphthalmoscopyNitroprusside13-lined ground squirreladaptive opticscone-dominantphotoreceptorsretinal degenerationretinal imaging

Identifiers

PMID38725382
PMCPMC11106521

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.