ArticleHeliyon2024
The abnormalities of lipid metabolism in children and adolescents with major depressive disorder and relationship with suicidal ideation and attempted suicide.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk Factors for Suicide Attempts in Chinese Patients with Major Depressive Disorder: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Pooled it
- Social jetlag and depressive symptoms among young people: a systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- Uncovering the metabolomic signatures in adolescent depression using a targeted metabolomics approach.BMC psychiatry · 2026Article
- Construction and Verification of a Risk Prediction Model for Suicidal Ideation in Patients With Bipolar Disorder: A Machine Learning Analysis.Alpha psychiatry · 2026Article
- The associations of insomnia symptoms and clinical features as well as blood metabolic parameters in adolescents with major depressive disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Immune-metabolic dysregulation and suicide risk in adolescents with major depressive disorder: a cross-sectional study.BMC psychiatry · 2026Article
- Factors influencing suicidal ideation in Chinese adolescents with first-episode depressive disorder: a cross-sectional study.BMC psychology · 2026Article
- Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review.Frontiers in pediatrics · 2026Review
- Thyroid-stimulating hormone, fasting blood glucose and suicidal ideation in Chinese adolescents with major depressive disorder: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.Translational psychiatry · 2025Review
- (-)-Epigallocatechin Gallate Ameliorates Chronic Stress-Induced Depression-Like Behavior in Rats by Inhibiting the NF-κB/Caspase-1 Signaling Pathway and Reducing IL-1β and IL-18 Expression.Food science & nutrition · 2025Article
- Article
- Prevalence and Pathogenic Factors of Thyroid Dysfunction in First-Episode and Drug-Naïve Major Depressive Disorder Patients With Fasting Blood Glucose Abnormalities in Early- and Late-Onset Age.Depression and anxiety · 2025Article
- Higher levels of total cholesterol/high-density lipoprotein cholesterol ratios are associated with an increased risk of suicidal behavior in children and adolescents with depressive disorders.Frontiers in psychiatry · 2025Article
- Prevalence and clinical correlates of impaired fasting blood glucose in children and adolescents with depressive disorder and relationship with triglyceride and high-density lipoprotein ratio.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Major depressive disorder (MDD) is a widespread health issue in many countries, which has an extremely negative impact on the health of children and adolescents in particular. In the context of depression and metabolic disorders, dyslipidemia and metabolism-related problems become more prominent comorbidities. However, they continue to be the main barrier to the successful recovery of the clinical progress. In this study we investigated the rate of dyslipidemia, additional risk factors among Chinese children and adolescents with MDD, and association of the suicidal behavior with lipid levels. Methods: The study took 756 people from the Third People's Hospital of Fuyang between January 2020 and December 2021, aged between 8 and 18, with major depressive disorders diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). We determined the FBG (fasting blood glucose) and lipid parameters in all subjects and also investigated the history of suicidal ideation, the cases of attempted suicide, and the scores of depressive symptoms. Sociodemographic and clinical data were gathered and analyzed using the SPSS-23.0 version. Results: The prevalence of hypercholesterolemia, hypertriglyceridemia, high LDL-C, and low HDL-C were 5.42 % (41/756), 10.58 % (80/756), 3.84 % (29/756) and 5.42 % (41/756) respectively. For hypercholesterolemia and hypertriglyceridemia, they were positive associated with suicidal ideation and suicide attempts, and the positive correlation is shown between low HDL-C levels and suicide attempts. Nevertheless, non-ideation and inversely suicidal attempts were not discovered among high-LDL-C subjects. Logistic analysis showed that high levels of FBG ( Conclusion: The high prevalence of dyslipidemia in childhood and adolescence among children and adolescents with depressive disorder has become a public health issue. Hypercholesterolemia and hypertriglyceridemia showed a positive correlation with suicidal thoughts and suicidal attempts. Monitoring the incidence of suicidal thoughts and attempts among them would carry some predictor meaning in therapy and for jumping back to health.
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