Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts to

Pamela Weathers, Melissa Towler, Bushra Hafeez Kiani, David Dolivo, Tanja Dominko

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Molecules (Basel, Switzerland) · 2026
Article
Potential Cosmetic Applications of Dihydroartemisinin.Molecules (Basel, Switzerland) · 2026
Article
Medicinal plants as more sustainable therapeutic solutions:Global health economics and sustainability · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pamela WeathersDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.

Melissa TowlerDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.

Bushra Hafeez KianiDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.ORCID 0000-0003-0748-9745

David DolivoDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.ORCID 0000-0002-6965-4294

Tanja DominkoDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.

Funding

Study how the liver alters bioavailability of artemisinin when delivered from the dried leaves of the plant Artemisia annua vs as pure drug.R15AT008277 · NCCIH · WORCESTER POLYTECHNIC INSTITUTE · PI WEATHERS, PAMELA J · 2014 to 2018

$953k

atelier temenos NoneNCCIH NIH HHS 2R15AT008277-02NCCIH NIH HHS R15 AT008277

6 · The paper itself

Abstract

Fibrosis is a ubiquitous pathology, and prior studies have indicated that various artemisinin (ART) derivatives (including artesunate (AS), artemether (AM), and dihydroartemisinin (DHA)) can reduce fibrosis in vitro and in vivo. The medicinal plant

Indexed as

ArtemisiaArtemisininsFibroblastsFibrosisActinsArtemetherArtesunateCell SurvivalGene Expression RegulationHumansMatrix Metalloproteinase 1Matrix Metalloproteinase 3Plant ExtractsSkinACTA2 protein, humanActinsArtemetherartemisininArtemisininsartenimolArtesunateMatrix Metalloproteinase 1Matrix Metalloproteinase 3MMP1 protein, humanMMP3 protein, humanPlant ExtractsartemetherArtemisia afraArtemisia annuaartemisininartesunatedihydroartemisinintea infusionα-SMA

Identifiers

PMID38731597

DOI10.3390/molecules29092107

PMCPMC11085156

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.