Evidence map›Paper›PMID 38731813›Full record

ArticleInternational journal of molecular sciences2024

BMP Stimulation Differentially Affects Phosphorylation and Protein Stability of β-Catenin in Breast Cancer Cell Lines.

Mustafa Ilhan, Nurcan Hastar, Branka Kampfrath, Deniz Neslihan Spierling, Jerome Jatzlau, Petra Knaus

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mustafa IlhanInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Nurcan HastarInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Branka KampfrathInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Deniz Neslihan SpierlingInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Jerome JatzlauInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0002-1757-0267
Petra KnausInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0003-2492-1667

Funding

Deutsche Forschungsgemeinschaft BSIODeutsche Forschungsgemeinschaft DFG-SFB1444Sonnenfeld Foundation Fellowship Ilhan
6 · The paper itself

Abstract

Increased expression and nuclear translocation of β-CATENIN is frequently observed in breast cancer, and it correlates with poor prognosis. Current treatment strategies targeting β-CATENIN are not as efficient as desired. Therefore, detailed understanding of β-CATENIN regulation is crucial. Bone morphogenetic proteins (BMP) and Wingless/Integrated (WNT) pathway crosstalk is well-studied for many cancer types including colorectal cancer, whereas it is still poorly understood for breast cancer. Analysis of breast cancer patient data revealed that

Indexed as

beta CateninBone Morphogenetic ProteinsBreast NeoplasmsProtein StabilityBone Morphogenetic Protein 2Cell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsPhosphorylationSmad4 Proteinbeta CateninBone Morphogenetic Protein 2Bone Morphogenetic ProteinsCTNNB1 protein, humanSmad4 ProteinSMAD4 protein, humanBMPbreast cancercrosstalkWNTβ-CATENIN

Identifiers

PMID38731813
PMCPMC11083028

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.