Evidence map›Paper›PMID 38731915›Full record

ArticleInternational journal of molecular sciences2024

Single-Cell Transcriptional Profile Construction of Rat Pituitary Glands before and after Sexual Maturation and Identification of Novel Marker

Qing-Hua Huang, Guo-Kun Zhao, Hao-Qi Wang, Fan-Hao Wei, Jin-Yu Zhang, Jia-Bao Zhang, Fei Gao, Bao Yuan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qing-Hua HuangDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.
Guo-Kun ZhaoDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.
Hao-Qi WangDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.
Fan-Hao WeiDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.
Jin-Yu ZhangDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.
Jia-Bao ZhangDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.ORCID 0000-0001-8533-4744
Fei GaoDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.ORCID 0000-0003-3996-2509
Bao YuanDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.ORCID 0000-0003-3490-0755

Funding

National Natural Science Foundation of China 32172729National Natural Science Foundation of China 32372882
6 · The paper itself

Abstract

The mammalian pituitary gland drives highly conserved physiological processes such as somatic cell growth, pubertal transformation, fertility, and metabolism by secreting a variety of hormones. Recently, single-cell transcriptomics techniques have been used in pituitary gland research. However, more studies have focused on adult pituitary gland tissues from different species or different sexes, and no research has yet resolved cellular differences in pituitary gland tissue before and after sexual maturation. Here, we identified a total of 15 cell clusters and constructed single-cell transcriptional profiles of rats before and after sexual maturation. Furthermore, focusing on the gonadotrope cluster, 106 genes were found to be differentially expressed before and after sexual maturation. It was verified that

Indexed as

GonadotrophsPituitary GlandSexual MaturationSingle-Cell AnalysisAnimalsBiomarkersFemaleFollicle Stimulating HormoneGene Expression ProfilingMaleRatsTranscriptomeBiomarkersFollicle Stimulating Hormonepubertyrat pituitarysexual maturitysingle-cell RNA sequencingSPP1

Identifiers

PMID38731915
PMCPMC11083676

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.