Evidence map›Paper›PMID 38732004›Full record

ArticleInternational journal of molecular sciences2024

Fructosyl Amino Oxidase as a Therapeutic Enzyme in Age-Related Macular Degeneration.

Joris R Delanghe, Jose Diana Di Mavungu, Koen Beerens, Jonas Himpe, Nezahat Bostan, Marijn M Speeckaert, Henk Vrielinck, Anne Vral, Caroline Van Den Broeke, Manon Huizing and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joris R DelangheDepartment of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-5702-6792
Jose Diana Di MavunguDepartment of Green Chemistry and Technology, MSsmall Expertise Centre, Mass Spectrometry Analysis of Small Organic Molecules, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-7733-2941
Koen BeerensDepartment of Biotechnology, Faculty of Bioscience Engineering, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-6608-0443
Jonas HimpeDepartment of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.
Nezahat BostanAntwerp Biobank, Antwerp University Hospital, 2650 Antwerp, Belgium.
Marijn M SpeeckaertDepartment of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-9183-4390
Henk VrielinckDepartment of Solid State Sciences, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0003-4861-9630
Anne VralDepartment of Human Structure and Repair, Ghent University, 9000 Ghent, Belgium.
Caroline Van Den BroekeDepartment of Pathology, Ghent University Hospital, 9000 Ghent, Belgium.
Manon HuizingAntwerp Biobank, Antwerp University Hospital, 2650 Antwerp, Belgium.ORCID 0000-0001-5331-9486
Elisabeth Van AkenDepartment of Head and Skin, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0003-2418-701X

Funding

IOF Ghent University F2020/IOF-StarTT/034) IOF StarTT-project
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is an age-related disorder that is a global public health problem. The non-enzymatic Maillard reaction results in the formation of advanced glycation end products (AGEs). Accumulation of AGEs in drusen plays a key role in AMD. AGE-reducing drugs may contribute to the prevention and treatment of AGE-related disease. Fructosamine oxidase (FAOD) acts on fructosyl lysine and fructosyl valine. Based upon the published results of fructosamine 3-kinase (FN3K) and FAOD obtained in cataract and presbyopia, we studied ex vivo FAOD treatment as a non-invasive AMD therapy. On glycolaldehyde-treated porcine retinas, FAOD significantly reduced AGE autofluorescence (

Indexed as

Glycation End Products, AdvancedMacular DegenerationAmino Acid OxidoreductasesAnimalsHumansRetinaSwineamadoriaseAmino Acid OxidoreductasesGlycation End Products, Advancedageingage-related macular degenerationfructosyl amino oxidaseglycation

Identifiers

PMID38732004
PMCPMC11083825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.