Evidence map›Paper›PMID 38732005›Full record

ArticleInternational journal of molecular sciences2024

The Rise in Tubular pH during Hypercalciuria Exacerbates Calcium Stone Formation.

Farai C Gombedza, Samuel Shin, Jaclyn Sadiua, George B Stackhouse, Bidhan C Bandyopadhyay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Farai C GombedzaCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.ORCID 0000-0002-1977-6242
Samuel ShinCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.ORCID 0000-0002-3461-2844
Jaclyn SadiuaCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
George B StackhouseUrology Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
Bidhan C BandyopadhyayCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.ORCID 0000-0003-2364-8945

Funding

Calcium transport in kidney proximal tubule and calcium phosphate stone formationR01DK102043 · NIDDK · INSTITUTE FOR CLINICAL RESEARCH, INC. · PI BANDYOPADHYAY, BIDHAN CHANDRA · 2015 to 2019
$1.1M
NIDDK NIH HHS DK102043NIDDK NIH HHS R01 DK102043
6 · The paper itself

Abstract

In calcium nephrolithiasis (CaNL), most calcium kidney stones are identified as calcium oxalate (CaOx) with variable amounts of calcium phosphate (CaP), where CaP is found as the core component. The nucleation of CaP could be the first step of CaP+CaOx (mixed) stone formation. High urinary supersaturation of CaP due to hypercalciuria and an elevated urine pH have been described as the two main factors in the nucleation of CaP crystals. Our previous in vivo findings (in mice) show that transient receptor potential canonical type 3 (TRPC3)-mediated Ca

Indexed as

Calcium OxalateHypercalciuriaKidney CalculiMice, KnockoutAcetazolamideAnimalsCalciumCalcium PhosphatesDisease Models, AnimalHydrogen-Ion ConcentrationKidney Tubules, ProximalMaleMiceMice, Inbred C57BLNephrolithiasisTRPC Cation ChannelsAcetazolamideCalciumCalcium Oxalatecalcium phosphateCalcium PhosphatesTRPC3 cation channelTRPC Cation Channelsapoptosiscalcium nephrolithiasisfibrosishypercalciuriainflammationoxidative stressproximal tubulerenal tubular pH

Identifiers

PMID38732005
PMCPMC11084476

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.