Evidence map›Paper›PMID 38732052›Full record

ArticleInternational journal of molecular sciences2024

Hepatocyte-Specific

Dushan T Ghooray, Manman Xu, Hongxue Shi, Craig J McClain, Ming Song

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dushan T GhoorayDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Manman XuDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Hongxue ShiDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Craig J McClainDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40202, USA.ORCID 0000-0002-7219-8939
Ming SongDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40202, USA.ORCID 0000-0001-8459-6953

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ZHANG, XIANG · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Lipid metabolites can both potentiate and treat alcoholic hepatitisU01AA026936 · NIAAA · UNIVERSITY OF LOUISVILLE · PI JOSHI-BARVE, SWATI, MCCLAIN, CRAIG J. · 2018 to 2022
$1.2M
Summer Environmental Health Sciences Training ProgramT35ES014559 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Matthew C Cave, Daniel Joseph Conklin · 2006 to 2026
$751k
Pilot Trial UO1 DUR-928U01AA026934 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2018 to 2022
$356k
Dietary Fat and Alcoholic Liver DiseaseI01BX002996 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI MCCLAIN, CRAIG J. · 2017 to 2020
–
BLRD VA I01 BX002996NIAAA NIH HHS P50 AA024337NIAAA NIH HHS U01 AA026934NIAAA NIH HHS U01 AA026936NIDDK NIH HHS P30 DK020593NIGMS NIH HHS P20 GM113226NIH HHS P20GM113226NIH HHS P30DK020593NIH HHS P50AA024337NIH HHS T35ES014559NIH HHS U01AA026934NIH HHS U01AA026936
6 · The paper itself

Abstract

Fatty acid desaturase 1 (FADS1) is a rate-limiting enzyme in long-chain polyunsaturated fatty acid (LCPUFA) synthesis. Reduced activity of FADS1 was observed in metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of this study was to determine whether adeno-associated virus serotype 8 (AAV8) mediated hepatocyte-specific overexpression of

Indexed as

Delta-5 Fatty Acid DesaturaseDiet, WesternFatty Acid DesaturasesHepatocytesAnimalsDependovirusDisease Models, AnimalFructoseLiverMalePhenotypeRatsRats, Sprague-DawleyTriglyceridesDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFatty Acid DesaturasesFructoseTriglyceridesarachidonic aciddihomo-γ-linolenic acidfatty acid desaturase 1insulin signalinglipidomicsMASLD

Identifiers

PMID38732052
PMCPMC11084797

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.