ArticleNature communications2024
An integrated multi-omics approach reveals polymethoxylated flavonoid biosynthesis in Citrus reticulata cv. Chachiensis.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A beneficial bacterium mitigates drought stress by upregulating the flavonoid biosynthetic pathway inPlant signaling & behavior · 2026Article
- The Convergence of Biotechnological Strategies in Medicinal Plants: From Individual Approaches Toward an Integrated Systems Framework.International journal of molecular sciences · 2026Review
- A novel C5-Horticulture research · 2026Article
- Metabolomics Reveals the Dynamic Characteristics of Flavonoids During the Different Developmental Stages ofCurrent issues in molecular biology · 2026Article
- Intercrops Maintain Orchard Soil Nutrients Accumulation with Variation in Soil Microbiome Composition and Function.Plants (Basel, Switzerland) · 2026Article
- Integrated Flavoromics and Metabolomics Reveal Aroma and Bioactive Characteristics of Six Mainstream Citri Reticulatae Pericarpium Cultivars.Foods (Basel, Switzerland) · 2026Article
- Geographical Discrimination of Xinhui Citri Reticulatae Pericarpium by DART-QTOF-MS.Foods (Basel, Switzerland) · 2026Article
- Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identification of Citri Reticulatae Pericarpium (Chenpi) From Different Cultivars via LC-MS/MS and UPLC Coupled With Multivariate Chemometrics Analysis.Food science & nutrition · 2026Article
- Article
- Location and growth period influence the bioactive compounds of Angelica sinensis (Oliv.) diels: multi-omics insights.BMC plant biology · 2026Article
- Multi-omics analyses of Dracocephalum moldavica L. reveal two flavonoid glycosyltransferases in tilianin biosynthesis.BMC genomics · 2026Article
- A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in Artemisia capillaris.Plant biotechnology journal · 2026Article
- Metabolic profiling of red-fleshed apple and functional characterization of MdERF072 in anthocyanin biosynthesis.BMC plant biology · 2025Article
- Genomic resources and genetic improvement of vital tropical and subtropical fruit crops: current status and prospects.AoB PLANTS · 2025Review
- Exogenous proline regulates the antioxidation system and fruit quality of cherry tomatoes under chilling storage: Integrated physiological, metabolomic, and transcriptomic study.Food chemistry. Molecular sciences · 2025Article
- Multi-omics analyses reveal the effects of layerage and grafting on flavonoid synthesis and accumulation inHorticulture research · 2025Article
- A high-quality chromosome-scale genome assembly of Xingan mandarin (Citrus reticulata 'Xingan'), a primitive Mandarin type.Scientific data · 2025Article
- Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast.Cell discovery · 2025Article
- Genome-Wide Characterization of thePlants (Basel, Switzerland) · 2025Article
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15 authors.
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Abstract
Citrus reticulata cv. Chachiensis (CRC) is an important medicinal plant, its dried mature peels named "Guangchenpi", has been used as a traditional Chinese medicine to treat cough, indigestion, and lung diseases for several hundred years. However, the biosynthesis of the crucial natural products polymethoxylated flavonoids (PMFs) in CRC remains unclear. Here, we report a chromosome-scale genome assembly of CRC with the size of 314.96 Mb and a contig N50 of 16.22 Mb. Using multi-omics resources, we discover a putative caffeic acid O-methyltransferase (CcOMT1) that can transfer a methyl group to the 3-hydroxyl of natsudaidain to form 3,5,6,7,8,3',4'-heptamethoxyflavone (HPMF). Based on transient overexpression and virus-induced gene silencing experiments, we propose that CcOMT1 is a candidate enzyme in HPMF biosynthesis. In addition, a potential gene regulatory network associated with PMF biosynthesis is identified. This study provides insights into PMF biosynthesis and may assist future research on mining genes for the biosynthesis of plant-based medicines.
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