ArticlePloS one2024
Effect of chemotherapy on prognosis in patients with primary pancreatic signet ring cell carcinoma: A large real-world study based on machine learning.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Construction and testing of a nomogram for patients with pancreatic signet-ring cell carcinoma and analysis of treatment-related survival differences: a study based on the Surveillance, Epidemiology, and End Results (SEER) database.Translational cancer research · 2026Article
- Association of surgery with survival in small cell carcinoma of the digestive system: a population-based observational study using machine learning.Scientific reports · 2026Observational
- Primary pancreatic signet ring cell carcinoma: molecular mechanisms and advances in clinical diagnosis and treatment.World journal of surgical oncology · 2025Review
- TyG-BMI index as a valuable risk of acute kidney injury in patients with heart failure: Insights from the MIMIC-IV and eICU cohorts.Journal of diabetes investigation · 2025Article
- Depressive Symptoms and Associated Factors Among Middle-Aged and Older Patients with Chronic Kidney Disease: Gender Differences Based on a Health Ecological Model.Healthcare (Basel, Switzerland) · 2025Article
- Comprehensive conditional survival analysis of pancreatic signet ring cell carcinoma: chemotherapy's role and predictive model development using the SEER database.Discover oncology · 2025Article
- Development and validation of machine learning nomograms for predicting survival in stage IV pancreatic cancer: A retrospective study.World journal of gastrointestinal oncology · 2025Article
- Primary pancreatic signet ring cell carcinoma: a case series from China and literature review.Discover oncology · 2025Article
- A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis.Frontiers in molecular biosciences · 2025Article
- Determinants of life satisfaction in older adults with diabetes in China: a national cross-sectional study.Frontiers in public health · 2025Article
- Development and validation of survival nomograms for patients with anaplastic thyroid carcinoma: a SEER program-based study.Discover oncology · 2024Article
- Competitive Risk Analysis of Prognosis in Older Adults with Sigmoid Colon Adenocarcinoma: A Population-Based Study.Cancer control : journal of the Moffitt Cancer CenterArticle
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4 authors.
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Abstract
backgroundPrimary pancreatic signet ring cell carcinoma (PSRCC), an extremely rare histologic variant of pancreatic cancer, has a poor prognosis. This study aimed to investigate the prognostic value of chemotherapy in PSRCC.
methodsPatients with PSRCC between 2000 and 2019 were identified using the Surveillance Epidemiology and End Results (SEER) database. The main outcomes in this study were cancer-specific survival (CSS) and overall survival (OS). The baseline characteristics of patients were compared using Pearson's Chi-square test. Kaplan-Meier analysis was used to generate the survival curves. Least absolute shrinkage and selection operator (LASSO), univariate and multivariate Cox regression models, and Random Survival Forest model were used to analyze the prognostic variables for OS and CSS. The variance inflation factors (VIFs) were used to analyze whether there was an overfitting problem.
resultsA total of 588 patients were identified. Chemotherapy was an independent prognostic factor for OS and CSS, and significantly associated with OS (HR = 0.33, 95% CI = 0.27-0.40, P <0.001) and CSS (HR = 0.32, 95% CI = 0.26-0.39, P <0.001).
conclusionsChemotherapy showed beneficial effects on OS and CSS in patients with PSRCC and should be recommended in clinical practice.
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