Evidence map›Paper›PMID 38740431›Full record

ArticleLife science alliance2024

Timing of TORC1 inhibition dictates Pol III involvement in

Yasir Malik, Isabel Goncalves Silva, Rene Rivera Diazgranados, Colin Selman, Nazif Alic, Jennifer Ma Tullet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yasir MalikDivision of Natural Sciences, School of Biosciences, University of Kent, Canterbury, Kent.
Isabel Goncalves SilvaDivision of Natural Sciences, School of Biosciences, University of Kent, Canterbury, Kent.
Rene Rivera DiazgranadosDivision of Natural Sciences, School of Biosciences, University of Kent, Canterbury, Kent.
Colin SelmanInstitute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, Scotland.ORCID 0000-0002-8727-0593
Nazif AlicUCL Department of Genetics, Evolution & Environment, Institute of Healthy Ageing, London, UK.
Jennifer Ma TulletDivision of Natural Sciences, School of Biosciences, University of Kent, Canterbury, Kent j.m.a.tullet@kent.ac.uk.ORCID 0000-0002-2037-526X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organismal growth and lifespan are inextricably linked. Target of Rapamycin (TOR) signalling regulates protein production for growth and development, but if reduced, extends lifespan across species. Reduction in the enzyme RNA polymerase III, which transcribes tRNAs and 5S rRNA, also extends longevity. Here, we identify a temporal genetic relationship between TOR and Pol III in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsLongevityMechanistic Target of Rapamycin Complex 1RNA Polymerase IIISignal TransductionAgingAnimalsTOR Serine-Threonine KinasesCaenorhabditis elegans ProteinsMechanistic Target of Rapamycin Complex 1RNA Polymerase IIITOR Serine-Threonine Kinases

Identifiers

PMID38740431
PMCPMC11091362

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.