Evidence map›Paper›PMID 38742885›Full record

ArticlemBio2024

Aspartyl peptidase May1 induces host inflammatory response by altering cell wall composition in the fungal pathogen

Yeqi Li, Benjamin Chadwick, Tuyetnhu Pham, Xiaofeng Xie, Xiaorong Lin

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. On-Resin Assembly of Macrocyclic Inhibitors ofJournal of medicinal chemistry · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yeqi LiDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.
Benjamin ChadwickDepartment of Plant Biology, University of Georgia, Athens, Georgia, USA.
Tuyetnhu PhamDepartment of Plant Biology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-4891-0823
Xiaofeng XieDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.
Xiaorong LinDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-3390-8387

Funding

Genetic and mechanistic analysis of carbon dioxide tolerance in Cryptococcus pathogenesisR01AI147541 · NIAID · UNIVERSITY OF IOWA · PI KRYSAN, DAMIAN J, LIN, XIAORONG · 2020 to 2025
$6.1M
Systematic investigation of GPI-anchored mannoproteins in Cryptococcus neoformansR21AI150641 · NIAID · UNIVERSITY OF GEORGIA · PI LIN, XIAORONG · 2020 to 2021
$415k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI147541HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI150641NIAID NIH HHS R01 AI147541NIAID NIH HHS R21 AI150641
6 · The paper itself

Abstract

IMPORTANCE: The fungal cell wall is a dynamic structure, monitoring and responding to internal and external stimuli. It provides a formidable armor to the fungus. However, in a weakened state, the cell wall also triggers host immune attack when PAMPs, including glucan, chitin, and mannoproteins, are exposed. In this work, we found that the aspartyl peptidase May1 impairs the cell wall of

Indexed as

Cell WallCryptococcus neoformansFungal ProteinsAnimalsAspartic Acid ProteasesChitinChitosanCryptococcosisHost-Pathogen InteractionsHydrogen-Ion ConcentrationInflammationMiceVirulenceAspartic Acid ProteasesChitinChitosanFungal Proteinscarbon dioxidechitin deacetylasechitin synthasechitosancryptococcosisinflammationpH sensing

Identifiers

PMID38742885
PMCPMC11237595

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.