Evidence mapPaperPMID 38745221Full record

ReviewJournal of biomedical science2024

Pivotal functions and impact of long con-coding RNAs on cellular processes and genome integrity.

Siddhant Sharma, Aicha Asma Houfani, Leonard J Foster

Abstract readReview
In one paragraph

Review in Journal of biomedical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Thermal adaptation crosstalk with azole response through lncRNA inbioRxiv : the preprint server for biology · 2026
    Article
  4. TheBiology · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. LncRNA-CFTBS enhancesVirulence · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Siddhant SharmaDepartment of Chemical and Biological Engineering, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.ORCID http://orcid.org/0000-0003-0967-4688
Aicha Asma HoufaniMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, 2185 E Mall, Vancouver, BC, V6T 1Z4, Canada.ORCID http://orcid.org/0000-0002-2139-8594
Leonard J FosterMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, 2185 E Mall, Vancouver, BC, V6T 1Z4, Canada. foster@msl.ubc.ca.ORCID http://orcid.org/0000-0001-8551-4817

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in uncovering the mysteries of the human genome suggest that long non-coding RNAs (lncRNAs) are important regulatory components. Although lncRNAs are known to affect gene transcription, their mechanisms and biological implications are still unclear. Experimental research has shown that lncRNA synthesis, subcellular localization, and interactions with macromolecules like DNA, other RNAs, or proteins can all have an impact on gene expression in various biological processes. In this review, we highlight and discuss the major mechanisms through which lncRNAs function as master regulators of the human genome. Specifically, the objective of our review is to examine how lncRNAs regulate different processes like cell division, cell cycle, and immune responses, and unravel their roles in maintaining genomic architecture and integrity.

Indexed as

RNA, Long NoncodingCell CycleGenome, HumanGenomic InstabilityHumansRNA, Long NoncodingCell cycleCell divisionHematopoiesisImmune responsesLong non-coding RNAs

Identifiers

PMID38745221
PMCPMC11092263

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.