Evidence map›Paper›PMID 38745666›Full record

ReviewFrontiers in immunology2024

Immunogenic cell death-based cancer vaccines: promising prospect in cancer therapy.

Jiandong Wang, Jinyuan Ma, Fangyuan Xie, Fengze Miao, Lei Lv, Yueying Huang, Xinyue Zhang, Junxia Yu, Zongguang Tai, Quangang Zhu and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  17. Review
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  19. Immunotherapy in Gastrointestinal Cancers: Current Insights.Clinical pharmacology : advances and applications · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiandong Wang *School of Pharmacy, Bengbu Medical College, Bengbu, Anhui, China.
Jinyuan Ma *Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Fangyuan Xie *Department of Pharmacy, Third Affiliated Hospital of Naval Medical University, Shanghai, China.
Fengze MiaoShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Lei LvDepartment of Pharmacy, Third Affiliated Hospital of Naval Medical University, Shanghai, China.
Yueying HuangDepartment of Pharmacy, Third Affiliated Hospital of Naval Medical University, Shanghai, China.
Xinyue ZhangShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Junxia YuSchool of Pharmacy, Bengbu Medical College, Bengbu, Anhui, China.
Zongguang TaiShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Quangang ZhuShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Leilei BaoDepartment of Pharmacy, Third Affiliated Hospital of Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor immunotherapy is a promising approach for addressing the limitations of conventional tumor treatments, such as chemotherapy and radiotherapy, which often have side effects and fail to prevent recurrence and metastasis. However, the effectiveness and sustainability of immune activation in tumor immunotherapy remain challenging. Tumor immunogenic cell death, characterized by the release of immunogenic substances, damage associated molecular patterns (DAMPs), and tumor associated antigens, from dying tumor cells (DTCs), offers a potential solution. By enhancing the immunogenicity of DTCs through the inclusion of more immunogenic antigens and stimulating factors, immunogenic cell death (ICD) based cancer vaccines can be developed as a powerful tool for immunotherapy. Integrating ICD nanoinducers into conventional treatments like chemotherapy, photodynamic therapy, photothermal therapy, sonodynamic therapy, and radiotherapy presents a novel strategy to enhance treatment efficacy and potentially improve patient outcomes. Preclinical research has identified numerous potential ICD inducers. However, effectively translating these findings into clinically relevant applications remains a critical challenge. This review aims to contribute to this endeavor by providing valuable insights into the

Indexed as

Cancer VaccinesImmunogenic Cell DeathNeoplasmsAnimalsAntigens, NeoplasmHumansImmunotherapyAntigens, NeoplasmCancer Vaccinescancer vaccinedying tumor cellsimmunogenic cell deathimmunotherapynanoinducers

Identifiers

PMID38745666
PMCPMC11092378

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.