Evidence map›Paper›PMID 38745836›Full record

ArticleFrontiers in physiology2024

Hemoglobin concentration and blood shift during dry static apnea in elite breath hold divers.

Thomas Kjeld, Thomas O Krag, Anders Brenøe, Ann Merete Møller, Henrik Christian Arendrup, Jens Højberg, Dan Fuglø, Søren Hancke, Lars Poulsen Tolbod, Lars Christian Gormsen and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Thomas KjeldCopenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Thomas O KragCopenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Anders BrenøeDepartment of Clinical Medicine, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Ann Merete MøllerDepartment of Anesthesiology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Henrik Christian ArendrupDepartment of Clinical Medicine, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Jens HøjbergDepartment of Cardiothoracic Anesthesiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Dan FugløDepartment of Nuclear Medicine, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Søren HanckeDepartment of Clinical Medicine, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Lars Poulsen TolbodDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.
Lars Christian GormsenDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.
John VissingCopenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Egon Godthaab HansenDepartment of Anesthesiology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Elite breath-hold divers (BHD) enduring apneas of more than 5 min are characterized by tolerance to arterial blood oxygen levels of 4.3 kPa and low oxygen-consumption in their hearts and skeletal muscles, similar to adult seals. Adult seals possess an adaptive higher hemoglobin-concentration and Bohr effect than pups, and when sedated, adult seals demonstrate a blood shift from the spleen towards the brain, lungs, and heart during apnea. We hypothesized these observations to be similar in human BHD. Therefore, we measured hemoglobin- and 2,3-biphosphoglycerate-concentrations in BHD ( Methods and results: After 4 min of apnea, left ventricular myocardial mass (LVMM) determined by Conclusion: Our results indicate: 1) Apnea training in BHD may increase hemoglobin concentration as an oxygen conserving adaptation similar to adult diving mammals. 2) The blood shift during dry apnea in BHD is 162% more from the lower extremities than from the spleen. 3) In contrast to the previous theory of the blood shift demonstrated in sedated adult seals, blood shift is not towards the heart during dry apnea in humans.

Indexed as

Bohr effectcardiac MR (CMR)cardiac PET/CTdual x-ray absorptiometry (DXA)free divinglower extremity blood volumemyocardial massspleen ultrasound examination

Identifiers

PMID38745836
PMCPMC11092981

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.