Evidence map›Paper›PMID 38746182›Full record

ArticlebioRxiv : the preprint server for biology2024

ESCRT disruption provides evidence against transsynaptic signaling functions for extracellular vesicles.

Erica C Dresselhaus, Kathryn P Harris, Cassandra R Blanchette, Kate Koles, Steven J Del Signore, Matthew F Pescosolido, Biljana Ermanoska, Mark Rozencwaig, Rebecca C Soslowsky, Michael J Parisi and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Erica C DresselhausDepartment of Biology, Brandeis University, Waltham, MA.
Kathryn P HarrisOffice of the Vice-Principal, Research and Innovation, University of Toronto, Mississauga, Mississauga, Canada.
Cassandra R BlanchetteDepartment of Biology, Brandeis University, Waltham, MA.
Kate KolesDepartment of Biology, Brandeis University, Waltham, MA.
Steven J Del SignoreDepartment of Biology, Brandeis University, Waltham, MA.
Matthew F PescosolidoDepartment of Biology, Brandeis University, Waltham, MA.
Biljana ErmanoskaDepartment of Biology, Brandeis University, Waltham, MA.
Mark RozencwaigDepartment of Biology, Brandeis University, Waltham, MA.
Rebecca C SoslowskyDepartment of Biology, Brandeis University, Waltham, MA.
Michael J ParisiDepartment of Neuroscience, Vickie and Jack Farber Institute of Neuroscience, Thomas Jefferson University, Bluemle Life Sciences Building, Philadelphia, PA.
Bryan A StewartDepartment of Biology, University of Toronto Mississauga, Mississauga, Canada; Department of Cell and Systems Biology University of Toronto, Toronto, Canada.
Timothy J MoscaDepartment of Neuroscience, Vickie and Jack Farber Institute of Neuroscience, Thomas Jefferson University, Bluemle Life Sciences Building, Philadelphia, PA.ORCID 0000-0003-3485-0719
Avital A RodalDepartment of Biology, Brandeis University, Waltham, MA.ORCID 0000-0002-2051-8304

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
Roles of Recycling Endosomes in Neuronal Extracellular Vesicle Cargo TrafficR01NS103967 · NINDS · BRANDEIS UNIVERSITY · PI Avital Adah Rodal · 2018 to 2026
$4.5M
Molecular and cellular mechanisms that underlie synaptic maturationR01NS110907 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI MOSCA, TIMOTHY J. · 2019 to 2023
$2.1M
Abberior 3D-STED microscope for super-resolution imagingS10OD034223 · OD · BRANDEIS UNIVERSITY · PI RODAL, AVITAL ADAH · 2023 to 2023
$1.2M
Mechanisms of presynaptic of multivesicular body traffic underlying exosome releaseF32NS120909 · NINDS · BRANDEIS UNIVERSITY · PI DRESSELHAUS, ERICA · 2021 to 2022
$102k
NIH HHS P40 OD018537NIH HHS S10 OD034223NINDS NIH HHS F32 NS120909NINDS NIH HHS R01 NS103967NINDS NIH HHS R01 NS110907
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are released by many cell types including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materials. We show that loss of multivesicular endosome-generating ESCRT (endosomal sorting complex required for transport) machinery disrupts release of EV cargoes from

Indexed as

Amyloid Precursor ProteinDraperDrosophilaendosomeESCRTEviexosomeextracellular vesicleHrsNeuroglianShrubsynapseSynaptotagmin-4Tsg101Vps4Wingless

Identifiers

PMID38746182
PMCPMC11092503

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.