Evidence map›Paper›PMID 38746309›Full record

ArticleResearch square2024

Cell competition drives bronchiolization and pulmonary fibrosis.

Rachel Warren, Kylie Klinkhammer, Handeng Lyu, Changfu Yao, Barry Stripp, Stijn P De Langhe

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Rachel WarrenDepartment of Medicine, Division of Pulmonary and Critical Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Kylie KlinkhammerDepartment of Medicine, Division of Pulmonary and Critical Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Handeng LyuDepartment of Medicine, Division of Pulmonary and Critical Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Changfu YaoWomen's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0003-1357-5017
Barry StrippWomen's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0003-4348-2137
Stijn P De LangheDepartment of Medicine, Division of Pulmonary and Critical Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3867-4572

Funding

Cell competition in pulmonary fibrosis and ARDSR35HL161169 · NHLBI · MAYO CLINIC ROCHESTER · PI Stijn Piet Johan De Langhe · 2022 to 2026
$4.7M
Interdisciplinary Training in Lung Physiology and Biomedical EngineeringT32HL105355 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2012 to 2021
$3.9M
HL-Lung stem cells and their niches.R01HL132156 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LANGHE, STIJN PIET JOHAN · 2016 to 2019
$2.0M
Epithelial stem cell hippo signaling in pulmonary fibrosisR01HL146461 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LANGHE, STIJN PIET JOHAN · 2019 to 2021
$1.6M
NHLBI NIH HHS R01 HL132156NHLBI NIH HHS R01 HL146461NHLBI NIH HHS R35 HL161169NHLBI NIH HHS T32 HL105355
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from the maladaptive differentiation of lung stem cells into bronchial epithelial cells rather than into alveolar type 1 (AT1) cells, which are responsible for gas exchange. Here, we report that healthy lungs maintain their stem cells through tonic Hippo and β-catenin signaling, which promote Yap/Taz degradation and allow for low level expression of the Wnt target gene

Identifiers

PMID38746309
PMCPMC11092845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.