Evidence map›Paper›PMID 38746415›Full record

ArticlebioRxiv : the preprint server for biology2025

VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300.

Susu Guo, Xiaodi Hu, Jennifer L Cotton, Lifang Ma, Qi Li, Jiangtao Cui, Yongjie Wang, Ritesh P Thakare, Zhipeng Tao, Y Tony Ip and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Susu GuoDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No 241, West Huaihai Road, Shanghai, P. R., 200030, China.
Xiaodi HuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.
Jennifer L CottonDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.
Lifang MaDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No 241, West Huaihai Road, Shanghai, P. R., 200030, China.
Qi LiDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.
Jiangtao CuiDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No 241, West Huaihai Road, Shanghai, P. R., 200030, China.
Yongjie WangDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No 241, West Huaihai Road, Shanghai, P. R., 200030, China.
Ritesh P ThakareDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.
Zhipeng TaoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 01605, USA.
Y Tony IpProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.
Xu WuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 01605, USA.
Jiayi WangDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No 241, West Huaihai Road, Shanghai, P. R., 200030, China.
Junhao MaoDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.ORCID 0000-0003-1980-1177

Funding

Targeting dynamic palmitoylation of TEAD transcription factorsR01CA238270 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAO, JUNHAO, WU, XU · 2019 to 2023
$2.7M
Dependence for TEAD transcription factors in intestinal development and polyposisR01DK127180 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MAO, JUNHAO · 2020 to 2024
$1.9M
Mechanism of YAP/TAZ crosstalk with Wnt signalingR01DK127207 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MAO, JUNHAO · 2021 to 2024
$1.5M
NCI NIH HHS R01 CA238270NIDDK NIH HHS R01 DK127180NIDDK NIH HHS R01 DK127207
6 · The paper itself

Abstract

Studies on Hippo pathway regulation of tumorigenesis largely center on YAP and TAZ, the transcriptional co-regulators of TEAD. Here, we present an oncogenic mechanism involving VGLL and TEAD fusions that is Hippo pathway-related but YAP/TAZ-independent. We characterize two recurrent fusions, VGLL2-NCOA2 and TEAD1-NCOA2, recently identified in spindle cell rhabdomyosarcoma. We demonstrate that in contrast to VGLL2 and TEAD1, the fusion proteins are strong activators of TEAD-dependent transcription, and their function does not require YAP/TAZ. Furthermore, we identify that VGLL2 and TEAD1 fusions engage specific epigenetic regulation by recruiting histone acetyltransferase p300 to control TEAD-mediated transcriptional and epigenetic landscapes. We showed that small molecule p300 inhibition can suppress fusion proteins-induced oncogenic transformation both

Indexed as

fusionHippo signaling pathwayNCOA2p300TEAD1VGLL2

Identifiers

PMID38746415
PMCPMC11092657

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.