Evidence map›Paper›PMID 38746418›Full record

ArticlebioRxiv : the preprint server for biology2024

A multi-organ map of the human immune system across age, sex and ethnicity.

S Mangiola, M Milton, N Ranathunga, Csn Li-Wai-Suen, A Odainic, E Yang, W Hutchison, A Garnham, J Iskander, B Pal and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

S MangiolaWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0001-7474-836X
M MiltonWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
N RanathungaWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Csn Li-Wai-SuenWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0003-0529-0804
A OdainicThe Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
E YangWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
W HutchisonWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
A GarnhamWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0002-8312-8450
J IskanderWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0002-3426-4376
B PalOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.ORCID 0000-0002-3684-4331
V YadavSystems Biology of Aging Laboratory, Columbia University; New York, USA.ORCID 0000-0003-2345-2846
Jfj RosselloMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC 3052, Australia.ORCID 0000-0003-3885-8777
V J CareyChanning Division of Network Medicine, Mass General Brigham, Harvard Medical School, Harvard University, Boston, USA.ORCID 0000-0003-4046-0063
M MorganDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, NY, USA.ORCID 0000-0002-5874-8148
S BedouiThe Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-7443-0543
A KalliesThe Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-6312-6968
A T PapenfussWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0002-1102-8506

Funding

Project-002U41HG004059 · NHGRI · ROSWELL PARK CANCER INSTITUTE CORP · PI MORGAN, MARTIN T · 2011 to 2020
$13.2M
Cancer Genomics:Integrative and Scalable Solutions in R / BioconductorU24CA180996 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MORGAN, MARTIN T, WALDRON, LEVI · 2014 to 2023
$6.9M
NCI NIH HHS U24 CA180996NHGRI NIH HHS U41 HG004059
6 · The paper itself

Abstract

Understanding tissue biology's heterogeneity is crucial for advancing precision medicine. Despite the centrality of the immune system in tissue homeostasis, a detailed and comprehensive map of immune cell distribution and interactions across human tissues and demographics remains elusive. To fill this gap, we harmonised data from 12,981 single-cell RNA sequencing samples and curated 29 million cells from 45 anatomical sites to create a comprehensive compositional and transcriptional healthy map of the healthy immune system. We used this resource and a novel multilevel modelling approach to track immune ageing and test differences across sex and ethnicity. We uncovered conserved and tissue-specific immune-ageing programs, resolved sex-dependent differential ageing and identified ethnic diversity in clinically critical immune checkpoints. This study provides a quantitative baseline of the immune system, facilitating advances in precision medicine. By sharing our immune map, we hope to catalyse further breakthroughs in cancer, infectious disease, immunology and precision medicine.

Indexed as

ageingBayesCELLxGENECompositional AnalysisethnicityHuman cell atlasImmune Body MapImmune Communicationsexsingle-cell RNA sequencing

Identifiers

PMID38746418
PMCPMC11092463

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.