Evidence map›Paper›PMID 38746526›Full record

ArticleJournal of neurosciences in rural practice

The profile of epilepsy and its characteristics in children with neurocutaneous syndromes.

Lokesh Saini, Swetlana Mukherjee, Pradeep Kumar Gunasekaran, Arushi Gahlot Saini, Chirag Ahuja, Indar Kumar Sharawat, Rajni Sharma, Ankita Bhati, Renu Suthar, Jitendra Kumar Sahu and 1 more

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Article in Journal of neurosciences in rural practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Lokesh SainiDepartment of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Swetlana MukherjeeDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, Uttarakhand, India.
Pradeep Kumar GunasekaranDepartment of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Arushi Gahlot SainiDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, Uttarakhand, India.
Chirag AhujaDepartment of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, Uttarakhand, India.
Indar Kumar SharawatDepartment of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Rajni SharmaDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, Uttarakhand, India.
Ankita BhatiDepartment of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Renu SutharDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, Uttarakhand, India.
Jitendra Kumar SahuDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, Uttarakhand, India.
Naveen SankhyanDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, Uttarakhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The profile of seizures in neurocutaneous syndromes is variable. We aimed to define the characteristics of epilepsy in children with neurocutaneous syndromes. Materials and Methods: Cross-sectional study over 18 months at a tertiary care pediatric hospital, including children with neurocutaneous syndromes aged between 1 and 15 years, using the 2017-International League Against Epilepsy classification. Results: In 119 children with neurocutaneous syndromes, 94 (79%) had epilepsy. In eight children with neurofibromatosis one with epilepsy, 5 (62.5%) had generalized motor tonic-clonic seizures, 1 (12.5%) had generalized motor epileptic spasms, 1 (12.5%) had generalized motor automatism, and 1 (12.5%) had a focal seizure. In 69 children with tuberous sclerosis complex with epilepsy, 30 (43.5%) had generalized motor epileptic spasms, 23 (33.3%) had focal seizures, and nine (13.0%) had generalized motor tonic-clonic seizures. In 14 children with Sturge-Weber syndrome with epilepsy, 13 (92.8%) had focal seizures, and 1 (7.2%) had generalized motor tonic seizures. Statistically significant associations were found between epilepsy and intellectual disability ( Conclusion: Profiling seizures in children with neurocutaneous syndromes are paramount in devising target-specific treatments as the epileptogenesis in each syndrome differs in the molecular pathways leading to the hyperexcitability state. Further multicentric studies are required to unravel better insights into the epilepsy profile of neurocutaneous syndromes.

Indexed as

EpilepsyNeurocutaneous syndromesNeurofibromatosis 1Sturge–Weber syndromeTuberous sclerosis complex

Identifiers

PMID38746526
PMCPMC11090591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.