Evidence map›Paper›PMID 38747002›Full record

ArticleJournal of materials chemistry. B2024

Investigation of a chondroitin sulfate-based bioactive coating for neural interface applications.

Vaishnavi Dhawan, Paige Nicole Martin, Xiaoming Hu, Xinyan Tracy Cui

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Chronic alteration of CabioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vaishnavi DhawanDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. xic11@pitt.edu.ORCID 0000-0002-4710-2392
Paige Nicole MartinDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. xic11@pitt.edu.ORCID 0000-0002-6907-2665
Xiaoming HuDepartment of Neurology, University of Pittsburgh, PA, USA.
Xinyan Tracy CuiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. xic11@pitt.edu.ORCID 0000-0002-0470-2005

Funding

Selective HDAC inhibition and therapeutic target genes: Identification of novel treatments for Bipolar DisorderR01MH106460 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2016 to 2024
$3.6M
Efficiency and Safety of Microstimulation Via Different Electrode MaterialsR01NS110564 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2024
$3.1M
Optimization and Delivery of Bioactive Coating for High Yield and Stable Neural RecordingU01NS113279 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2022
$2.4M
Bioengineering in Psychiatry Training ProgramT32MH119168 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, IBRAHIM, TAMER S · 2019 to 2023
$1.1M
NIMH NIH HHS R01 MH106460NIMH NIH HHS T32 MH119168NINDS NIH HHS R01 NS110564NINDS NIH HHS U01 NS113279
6 · The paper itself

Abstract

Invasive neural implants allow for high-resolution bidirectional communication with the nervous tissue and have demonstrated the ability to record neural activity, stimulate neurons, and sense neurochemical species with high spatial selectivity and resolution. However, upon implantation, they are exposed to a foreign body response which can disrupt the seamless integration of the device with the native tissue and lead to deterioration in device functionality for chronic implantation. Modifying the device surface by incorporating bioactive coatings has been a promising approach to camouflage the device and improve integration while maintaining device performance. In this work, we explored the novel application of a chondroitin sulfate (CS) based hydrophilic coating, with anti-fouling and neurite-growth promoting properties for neural recording electrodes. CS-coated samples exhibited significantly reduced protein-fouling

Indexed as

Chondroitin SulfatesCoated Materials, BiocompatibleAnimalsBiofoulingElectrodes, ImplantedMiceNeuronsSurface PropertiesChondroitin SulfatesCoated Materials, Biocompatible

Identifiers

PMID38747002
PMCPMC11152038

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.