Evidence map›Paper›PMID 38747044›Full record

ArticleAging cell2024

Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain.

Solal Chauquet, Emily F Willis, Laura Grice, Samuel B R Harley, Joseph E Powell, Naomi R Wray, Quan Nguyen, Marc J Ruitenberg, Sonia Shah, Jana Vukovic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. BetaBiomedicines · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Solal ChauquetInstitute for Molecular Bioscience, the University of Queensland, Saint Lucia, Queensland, Australia.
Emily F WillisSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Saint Lucia, Queensland, Australia.
Laura GriceInstitute for Molecular Bioscience, the University of Queensland, Saint Lucia, Queensland, Australia.
Samuel B R HarleyQueensland Brain Institute, the University of Queensland, Saint Lucia, Queensland, Australia.
Joseph E PowellInstitute for Molecular Bioscience, the University of Queensland, Saint Lucia, Queensland, Australia.
Naomi R WrayInstitute for Molecular Bioscience, the University of Queensland, Saint Lucia, Queensland, Australia.
Quan NguyenInstitute for Molecular Bioscience, the University of Queensland, Saint Lucia, Queensland, Australia.
Marc J RuitenbergSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Saint Lucia, Queensland, Australia.
Sonia ShahInstitute for Molecular Bioscience, the University of Queensland, Saint Lucia, Queensland, Australia.
Jana VukovicSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Saint Lucia, Queensland, Australia.ORCID 0000-0002-3739-1688

Funding

Australian Research CouncilNational Health and Medical Research CouncilSylvia and Charles Viertel Charitable Foundation
6 · The paper itself

Abstract

Slowing and/or reversing brain ageing may alleviate cognitive impairments. Previous studies have found that exercise may mitigate cognitive decline, but the mechanisms underlying this remain largely unclear. Here we provide unbiased analyses of single-cell RNA sequencing data, showing the impacts of exercise and ageing on specific cell types in the mouse hippocampus. We demonstrate that exercise has a profound and selective effect on aged microglia, reverting their gene expression signature to that of young microglia. Pharmacologic depletion of microglia further demonstrated that these cells are required for the stimulatory effects of exercise on hippocampal neurogenesis but not cognition. Strikingly, allowing 18-month-old mice access to a running wheel did by and large also prevent and/or revert T cell presence in the ageing hippocampus. Taken together, our data highlight the profound impact of exercise in rejuvenating aged microglia, associated pro-neurogenic effects and on peripheral immune cell presence in the ageing female mouse brain.

Indexed as

AgingBrainMicrogliaPhysical Conditioning, AnimalT-LymphocytesAnimalsFemaleMiceMice, Inbred C57BLactive place avoidanceborder‐associated macrophagesbrain ageingcognitiondisease‐associated microglianeuroinflammationT cells

Identifiers

PMID38747044
PMCPMC11258432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.