Evidence map›Paper›PMID 38748287›Full record

ArticleEuropean journal of nutrition2024

Ginseng-DF ameliorates intestinal mucosal barrier injury and enhances immunity in immunosuppressed mice by regulating MAPK/NF-κB signaling pathways.

Ji-Yue Sha, Ke-Cheng Chen, Zheng-Bo Liu, Wei Li, Yu-Shun Lu, Shuang Liu, Jian-Kai Ma, Di Qu, Yin-Shi Sun

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Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Flavonoids ofVeterinary sciences · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ji-Yue Sha *Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, 130112, China.
Ke-Cheng Chen *Goldenwell Biotech, Inc., Reno, NV, 89501, USA.
Zheng-Bo LiuInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, 130112, China.
Wei LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Yu-Shun LuInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, 130112, China.
Shuang LiuLooking Up 9 Starry Sky Medical Research Center, Siping, 136000, China. jhssjt@163.com.
Jian-Kai MaBaker (Jilin) Special Medical Health Industry Co., Ltd., Changchun, 130102, China.
Di QuInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, 130112, China.
Yin-Shi SunInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, 130112, China. sunyinshi2015@163.com.ORCID http://orcid.org/0000-0002-1889-4984

Funding

Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences CAAS-ASTIP-2021-ISAPSJilin Scientific and Technological Development Program 202301ZYTS352
6 · The paper itself

Abstract

purposeDietary fiber (DF) has a good application prospect in effectively restoring the integrity of the intestinal mucosal barrier. Ginseng-DF has good physicochemical properties and physiological activity and shows positive effects in enhancing immunity. The aim of this study was to investigate the protective effect of Ginseng-DF on intestinal mucosal barrier injury induced by cyclophosphamide (CTX) in immunosuppressed mice and its possible mechanism.

methodsThe effects of Gginseng-DF on immune function in mice were studied by delayed-type hypersensitivy, lymphocyte proliferation assay and NK cytotoxicity assay, the T lymphocyte differentiation and intestinal barrier integrity were analyzed by flow cytometry and western blot.

resultsGinseng-DF (2.5% and 5%) could attenuate the inhibition of DTH response by CTX, promote the transformation and proliferation of lymphocytes, and stimulate NK effector cell activity. At the same time, Ginseng-DF could restore the proportion of CD4

conclusionGinseng-DF can be used as a safe dietary supplement to enhance body immunity and reduce intestinal mucosal injury caused by CTX.

Indexed as

CyclophosphamideIntestinal MucosaNF-kappa BPanaxSignal TransductionAnimalsCytokinesImmunocompromised HostKiller Cells, NaturalMaleMAP Kinase Signaling SystemMiceMice, Inbred BALB CPlant ExtractsCyclophosphamideCytokinesNF-kappa BPlant ExtractsCTXGinseng-DFImmunosuppressionIntestinal mucosal barrier injuryMAPK/NF-κB signaling pathway

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.