Evidence map›Paper›PMID 38748578›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Misregulation of bromotyrosine compromises fertility in male

Qi Su, Bing Xu, Xin Chen, Steven E Rokita

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qi SuDepartment of Chemistry, The Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-7393-1696
Bing XuDepartment of Chemistry, The Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0003-4670-4612
Xin ChenHHMI, The Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-6990-0926
Steven E RokitaDepartment of Chemistry, The Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-2292-2917

Funding

Study epigenetic inheritance during development, homeostasis and regenerationR35GM127075 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Xin Chen · 2018 to 2026
$3.2M
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell LineageR01HD102474 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2020 to 2024
$1.7M
Switching Between One and Two Electron Mechanisms in the Nitroreductase SuperfamilyR01GM130937 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2019 to 2022
$1.3M
The Role of a Dehalogenase in Drosophila SpermatogenesisR21AI119540 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2015 to 2016
$428k
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD102474HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM130937HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM1270775HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) R21AI119540Howard Hughes Medical Institute (HHMI) n/aNIAID NIH HHS R21 AI119540NICHD NIH HHS R01 HD102474NIGMS NIH HHS R01 GM130937NIGMS NIH HHS R35 GM127075
6 · The paper itself

Abstract

Biological regulation often depends on reversible reactions such as phosphorylation, acylation, methylation, and glycosylation, but rarely halogenation. A notable exception is the iodination and deiodination of thyroid hormones. Here, we report detection of bromotyrosine and its subsequent debromination during

Indexed as

Drosophila ProteinsFertilitySpermatogenesisTyrosineAnimalsAnimals, Genetically ModifiedDrosophilaDrosophila melanogasterHydrolasesMaleDrosophila ProteinsHydrolasesTyrosinebromotyrosinedehalogenationdisruption of spermatogenesisDrosophilaflavoprotein

Identifiers

PMID38748578
PMCPMC11126969

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.