Evidence mapPaperPMID 38748847Full record

GuidelineEuropean journal of endocrinology2024

Clinical practice guidelines for the care of girls and women with Turner syndrome.

Claus H Gravholt, Niels H Andersen, Sophie Christin-Maitre, Shanlee M Davis, Anthonie Duijnhouwer, Aneta Gawlik, Andrea T Maciel-Guerra, Iris Gutmark-Little, Kathrin Fleischer, David Hong and 10 more

Registry-linked trialAbstract readPractice Guideline
In one paragraph

Guideline in European journal of endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06834594 (Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome), which is not on this map. Cited by 90 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 5 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06834594 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome: A Non-randomized Prospective Trial (The BOOST Study)

TypeinterventionalSponsorChildren's Mercy Hospital Kansas CityRan2025 to 2028Enrolled40ConditionsTurner Syndrome, Primary Ovarian Insufficiency (Poi)ArmsMicronized progesterone 200 MG, Micronized Progesterone 100 MG
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Pooled it
  5. Turner Syndrome and the Thyroid Function-A Systematic and Critical Review.International journal of molecular sciences · 2024
    Pooled it
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Comments on "Risk of autoimmune thyroid diseases in individuals with alopecia areata".Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. A Rare Coexistence of Turner Syndrome and Mycosis Fungoides: A Case ReportJournal of clinical research in pediatric endocrinology · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Claus H GravholtDepartment of Endocrinology, Aarhus University Hospital, 8200 Aarhus N, Denmark.ORCID 0000-0001-5924-1720
Niels H AndersenDepartment of Cardiology, Aalborg University Hospital, 9000 Aalborg, Denmark.
Sophie Christin-MaitreEndocrine and Reproductive Medicine Unit, Center of Rare Endocrine Diseases of Growth and Development (CMERCD), FIRENDO, Endo ERN Hôpital Saint-Antoine, Sorbonne University, Assistance Publique-Hôpitaux de Paris, 75012 Paris, France.ORCID 0000-0002-6057-6840
Shanlee M DavisDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, United States.
Anthonie DuijnhouwerDepartment of Cardiology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.
Aneta GawlikDepartments of Pediatrics and Pediatric Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Andrea T Maciel-GuerraArea of Medical Genetics, Department of Translational Medicine, School of Medical Sciences, State University of Campinas, 13083-888 São Paulo, Brazil.
Iris Gutmark-LittleCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, United States.ORCID 0000-0003-0135-4516
Kathrin FleischerDepartment of Reproductive Medicine, Nij Geertgen Center for Fertility, Ripseweg 9, 5424 SM Elsendorp, The Netherlands.
David HongDivision of Interdisciplinary Brain Sciences, Stanford University School of Medicine, Stanford, CA 94304, United States.
Karen O KleinRady Children's Hospital, University of California, San Diego, CA 92123, United States.
Siddharth K PrakashDepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, United States.ORCID 0000-0001-6341-9624
Roopa Kanakatti ShankarDivision of Endocrinology, Children's National Hospital, The George Washington University School of Medicine, Washington, DC 20010, United States.ORCID 0000-0001-9653-8865
David E SandbergSusan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109-2800, United States.ORCID 0000-0002-7389-8283
Theo C J SasDepartment the Pediatric Endocrinology, Sophia Children's Hospital, Rotterdam 3015 CN, The Netherlands.
Anne SkakkebækDepartment of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark.ORCID 0000-0001-9178-4901
Kirstine StochholmDepartment of Endocrinology, Aarhus University Hospital, 8200 Aarhus N, Denmark.ORCID 0000-0002-4408-3413
Janielle A van der VeldenDepartment of Pediatric Endocrinology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen 6500 HB, The Netherlands.
International Turner Syndrome Consensus Group
Philippe F BackeljauwCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, United States.ORCID 0000-0003-2398-9520

Funding

Independent Research Fund Denmark 0134-00406NICHD NIH HHS R01 HD093450Novo Nordisk Foundation NNF15OC0016474
6 · The paper itself

Abstract

Turner syndrome (TS) affects 50 per 100 000 females. TS affects multiple organs through all stages of life, necessitating multidisciplinary care. This guideline extends previous ones and includes important new advances, within diagnostics and genetics, estrogen treatment, fertility, co-morbidities, and neurocognition and neuropsychology. Exploratory meetings were held in 2021 in Europe and United States culminating with a consensus meeting in Aarhus, Denmark in June 2023. Prior to this, eight groups addressed important areas in TS care: (1) diagnosis and genetics, (2) growth, (3) puberty and estrogen treatment, (4) cardiovascular health, (5) transition, (6) fertility assessment, monitoring, and counselling, (7) health surveillance for comorbidities throughout the lifespan, and (8) neurocognition and its implications for mental health and well-being. Each group produced proposals for the present guidelines, which were meticulously discussed by the entire group. Four pertinent questions were submitted for formal GRADE (Grading of Recommendations, Assessment, Development and Evaluation) evaluation with systematic review of the literature. The guidelines project was initiated by the European Society for Endocrinology and the Pediatric Endocrine Society, in collaboration with members from the European Society for Pediatric Endocrinology, the European Society of Human Reproduction and Embryology, the European Reference Network on Rare Endocrine Conditions, the Society for Endocrinology, and the European Society of Cardiology, Japanese Society for Pediatric Endocrinology, Australia and New Zealand Society for Pediatric Endocrinology and Diabetes, Latin American Society for Pediatric Endocrinology, Arab Society for Pediatric Endocrinology and Diabetes, and the Asia Pacific Pediatric Endocrine Society. Advocacy groups appointed representatives for pre-meeting discussions and the consensus meeting.

Indexed as

Turner SyndromeAdolescentAdultChildEuropeFemaleHumansPubertycardiovascular healthco-morbidityhypogonadisminfertilityneurocognitiontransitionTurner syndrome

Identifiers

PMID38748847
PMCPMC11759048

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.