ArticleBMJ open2024
Body mass index and all-cause mortality in HUNT and UK biobank studies: revised non-linear Mendelian randomisation analyses.
Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed.
- Effect of Time-Restricted Eating on Metabolic Adaptation in Adults With Severe Obesity During Early Phase of Weight Loss.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Trial
- Widespread genetic effect heterogeneity impacts bias and power in nonlinear Mendelian randomization.medRxiv : the preprint server for health sciences · 2026Article
- A Cross-Sectional Analytical Study: Prevalence and Clinical Profile of Metabolic Syndrome Among Middle Eastern, Mainly Jordanians, Cohort Presented with Atherosclerotic Cardiovascular Disease.Vascular health and risk management · 2026Observational
- Redefining atherosclerotic cardiovascular disease patients with no standard modifiable risk factors "SMuRF-less": six rather than four risk factors. Analysis from the Jordan SMuRF-less Study.Frontiers in cardiovascular medicine · 2026Article
- No More Free Lunch: Challenges to Mendelian Randomization Due to Sample Selection and Complex Methods.The Journal of clinical endocrinology and metabolism · 2025Article
- Investigating the non-linear association between sleep duration and type 2 diabetes: conventional and Mendelian randomization analyses from the UK Biobank.Journal of diabetes investigation · 2025Article
- Introduction to Mendelian randomization.Annals of clinical epidemiology · 2025Article
- Association of advanced lung cancer inflammation index with all-cause and cardiovascular mortality in US patients with asthma.Frontiers in nutrition · 2025Article
- Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2024Article
- Association between nut consumption and mortality risk: a 20-year cohort study in Korea with a stratified analysis by health-related variables.Nutrition journal · 2024Article
- Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited.International journal of epidemiology · 2024Article
- Towards more reliable non-linear mendelian randomization investigations.European journal of epidemiology · 2024Article
- Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study.International journal of epidemiology · 2024Article
- Genetically predicted blood metabolites mediate relationships between gut microbiota and ovarian cancer: a Mendelian randomization study.Frontiers in cellular and infection microbiology · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo estimate the shape of the causal relationship between body mass index (BMI) and mortality risk in a Mendelian randomisation framework.
designMendelian randomisation analyses of two prospective population-based cohorts.
settingIndividuals of European ancestries living in Norway or the UK.
participants56 150 participants from the Trøndelag Health Study (HUNT) in Norway and 366 385 participants from UK Biobank recruited by postal invitation. OUTCOMES: All-cause mortality and cause-specific mortality (cardiovascular, cancer, non-cardiovascular non-cancer).
resultsA previously published non-linear Mendelian randomisation analysis of these data using the residual stratification method suggested a J-shaped association between genetically predicted BMI and mortality outcomes with the lowest mortality risk at a BMI of around 25 kg/m
conclusionThis research challenges findings from previous conventional observational epidemiology and Mendelian randomisation investigations that the lowest level of mortality risk is at a BMI level of around 25 kg/m
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.