Evidence map›Paper›PMID 38751621›Full record

ArticleACS pharmacology & translational science2024

Enantiomeric Agonists of the Type 2 Cannabinoid Receptor Reduce Retinal Damage during Proliferative Vitreoretinopathy and Inhibit Hyperactive Microglia

Alexander P Young, Anna-Maria Szczesniak, Karolynn Hsu, Melanie E M Kelly, Eileen M Denovan-Wright

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander P YoungDepartment of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.ORCID https://orcid.org/0000-0003-3395-2377
Anna-Maria SzczesniakDepartment of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Karolynn HsuDepartment of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Melanie E M KellyDepartment of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Eileen M Denovan-WrightDepartment of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are resident immune cells of the central nervous system (CNS) and propagate inflammation following damage to the CNS, including the retina. Proliferative vitreoretinopathy (PVR) is a condition that can emerge following retinal detachment and is characterized by severe inflammation and microglial proliferation. The type 2 cannabinoid receptor (CB

Identifiers

PMID38751621
PMCPMC11091991

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.