ArticleEuropean radiology2024
Electron density dual-energy CT can improve the detection of lumbar disc herniation with higher image quality than standard and virtual non-calcium images.
Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Improved interobserver agreement for perihematomal edema measurement using dual-layer spectral CT electron density imaging in intracerebral hemorrhage.Emergency radiology · 2026Article
- Quantitative spectral computed tomography biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease: a dual-layer detector computed tomography study.Quantitative imaging in medicine and surgery · 2026Article
- Detection of lumbar disc herniation and degeneration using photon-counting detector CT with virtual non-calcium imaging.European radiology · 2026Article
- Temporal bone dual-layer detector dual-energy computed tomography for identifying cholesteatoma.European radiology · 2026Article
- Spectral CT electron density for evaluation of lumbar intervertebral disk degeneration.PloS one · 2026Article
- Diagnostic performance of dual-energy CT for opportunistic detection of rotator cuff disease: a retrospective multireader study.Insights into imaging · 2025Article
- Electron Density and Effective Atomic Number of Normal-Appearing Adult Brain Tissues: Age-Related Changes and Correlation with Myelin Content.Tomography (Ann Arbor, Mich.) · 2025Article
- Dual-layer spectral detector CT electron density imaging: impressive technology for imaging characteristics of ground-glass nodules.Quantitative imaging in medicine and surgery · 2025Article
- Endoscopic Foraminotomy for the Treatment of Lumbar Neuro-Foramen Stenosis: Role of CT in Treatment Planning and Post-Operative Assessment.Life (Basel, Switzerland) · 2025Article
- Using Key Predictors in an SVM Model for Differentiating Spinal Fractures and Herniated Intervertebral Discs in Preoperative Anesthesia Evaluation.Diagnostics (Basel, Switzerland) · 2024Article
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Abstract
objectivesTo compare the diagnostic performance and image quality of dual-energy computed tomography (DECT) with electron density (ED) image reconstruction with those of DECT with standard CT (SC) and virtual non-calcium (VNCa) image reconstructions, for diagnosing lumbar disc herniation (L-HIVD).
methodsA total of 59 patients (354 intervertebral discs from T12/L1 to L5/S1; mean age, 60 years; 30 women and 29 men) who underwent DECT with spectral reconstruction and 3-T MRI within 2 weeks were enrolled between March 2021 and February 2022. Four radiologists independently assessed three image sets of randomized ED, SC, and VNCa images to detect L-HIVD at 8-week intervals. The coefficient of variance (CV) and the Weber contrast of the ROIs in the normal and diseased disc to cerebrospinal fluid space (NCR-normal/-diseased, respectively) were calculated to compare the image qualities of the noiseless ED and other series.
resultsOverall, 129 L-HIVDs were noted on MRI. In the detection of L-HIVD, ED showed a higher AUC and sensitivity than SC and VNCa; 0.871 vs 0.807 vs 833 (p = 0.002) and 81% vs 70% vs 74% (p = 0.006 for SC), respectively. CV was much lower in all measurements of ED than those for SC and VNCa (p < 0.001). Furthermore, NCR-normal and NCR-diseased were the highest in ED (ED vs SC in NCR-normal and NCR-diseased, p = 0.001 and p = 0.004, respectively; ED vs VNCa in NCR-diseased, p = 0.044).
conclusionCompared to SC and VNCa images, DECT with ED reconstruction can enhance the AUC and sensitivity of L-HIVD detection with a lower CV and higher NCR. CLINICAL RELEVANCE STATEMENT: To our knowledge, this is the first study to quantify the image quality of noiseless ED images. ED imaging may be helpful for detecting L-HIVD in patients who cannot undergo MRI. KEY POINTS: ED images have diagnostic potential, but relevant quantitative analyses of image quality are limited. ED images detect disc herniation, with a better coefficient of variance and normalized contrast ratio values. ED images could detect L-HIVD when MRI is not an option.
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