Evidence map›Paper›PMID 38755492›Full record

ArticleJournal of endocrinological investigation2024

Germline polymorphisms of the NOD2 pathway may predict the effectiveness of radioiodine in differentiated thyroid cancer treatment.

M Borowczyk, M Kaczmarek-Ryś, S Hryhorowicz, M Sypniewski, D Filipowicz, P Dobosz, M Oszywa, M Ruchała, K Ziemnicka

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M BorowczykDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland. martyna.borowczyk@gmail.com.ORCID http://orcid.org/0000-0002-4824-8131
M Kaczmarek-RyśInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
S HryhorowiczInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
M SypniewskiUniversity Cancer Diagnostic Center, Poznan University of Medical Sciences, Poznan, Poland.
D FilipowiczDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland.
P DoboszUniversity Cancer Diagnostic Center, Poznan University of Medical Sciences, Poznan, Poland.
M OszywaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland.
M RuchałaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland.
K ZiemnickaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland.

Funding

Directorate-General for Regional Policy Scholarship support for PhD students specializing in majors strategic for Wielkopolska's developmentNarodowe Centrum Nauki NN402287436
6 · The paper itself

Abstract

purposeDifferentiated thyroid cancer (DTC) presents a complex clinical challenge, especially in patients with distant metastases and resistance to standard treatments. This study aimed to investigate the influence of specific genes and their germline single nucleotide polymorphisms (SNPs) linked to both inflammatory processes and other neoplasms on the clinical and pathological characteristics of DTC, particularly their potential impact on radioiodine (RAI) treatment efficacy.

methodsThis retrospective analysis involved a cohort of 646 patients diagnosed with DTC after thyroidectomy. Study covering 1998-2014, updated in 2023, included 567 women and 79 men (median age: 49; range: 7-83). SNP selection targeted functional significance, while mutational status was assessed by pyrosequencing for comprehensive characterization. Patient genetic profiles were assessed for associations with disease characteristics, RAI response, and cancer pathology.

resultsSignificant correlations emerged between certain SNPs and DTC features. Notably, the NOD2 c.802 T > C variant (rs2066842) was identified as a marker distinguishing between papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC). Moreover, the c.802 T allele was associated with an enhanced response to RAI treatment, indicating a more substantial decrease in posttreatment stimulated thyroglobulin (sTg) concentrations. The NFKB1A allele c.126A (rs696) exhibited connections with lower FTC stages and a reduced probability of multifocality.

conclusionThis study explored the molecular mechanisms of particular SNPs, highlighting the role of NOD2 in innate immunity and the stress response, and its potential impact on RAI efficacy. This research underscores the clinical promise of SNP analysis and contributes to personalized treatment strategies for DTC, emphasizing the relevance of genetic factors in cancer progression and treatment outcomes.

Indexed as

Iodine RadioisotopesNod2 Signaling Adaptor ProteinPolymorphism, Single NucleotideThyroid NeoplasmsAdenocarcinoma, FollicularAdolescentAdultAgedAged, 80 and overBiomarkers, TumorChildFemaleFollow-Up StudiesGerm-Line MutationHumansMaleBiomarkers, TumorIodine RadioisotopesNOD2 protein, humanNod2 Signaling Adaptor ProteinChronic lymphocytic thyroiditisDifferentiated thyroid cancerRadioiodine treatmentSingle nucleotide polymorphismsThyroglobulin

Identifiers

PMID38755492
PMCPMC11549118

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.