ArticleEnvironmental health : a global access science source2024
Accommodating detection limits of multiple exposures in environmental mixture analyses: an overview of statistical approaches.
Article in Environmental health : a global access science source, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Environmental Mixture-Health Associations: Current Analytical Practice and Reporting Recommendations.China CDC weekly · 2026Article
- Interpreting Postdiagnosis Toenail Metal Measurements in Childhood Nephrotic Syndrome.Kidney international reports · 2026Article
- Exploring novel skin biomarkers related to pruritus in dialysis patients.International urology and nephrology · 2026Article
- Workflow for Statistical Analysis of Environmental Mixtures.Environmental health perspectives · 2026Review
- Multiple linear regression modeling with values below a lower limit of quantification - a statistical method comparison.BMC medical research methodology · 2026Article
- Potential role of maintaining physiological testosterone levels in improving glucose metabolism among normal-weight Japanese women: a pilot exploratory study.Frontiers in endocrinology · 2026Article
- Mediating effect of social determinants of health between race and phthalate biomarkers in pregnancy.Pregnancy (Hoboken, N.J.) · 2026Article
- Effects of mixed blood metals on hearing loss among steel workers: a case-control study.Frontiers in public health · 2026Article
- Prenatal Exposure to Emerging Pesticides and Childhood Allergy Risk: A Mixture Assessment in an Urban Birth Cohort.Environmental science & technology letters · 2025Article
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
- Uncovering Exposure Patterns of Metals, PFAS, Phthalates, and PAHs and Their Combined Effect on Liver Injury Markers.Journal of xenobiotics · 2025Article
- Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers.BMC research notes · 2025Article
- Association of joint exposure to organophosphorus flame retardants and phthalate acid esters with gestational diabetes mellitus: a nested case-control study.BMC pregnancy and childbirth · 2024Article
- The associations between exposure to mixed environmental endocrine disruptors and sex steroid hormones in men: a comparison of different statistical models.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIdentifying the impact of environmental mixtures on human health is an important topic. However, such studies face challenges when exposure measurements lie below limit of detection (LOD). While various approaches for accommodating a single exposure subject to LOD have been used, their impact on mixture analysis has not been thoroughly investigated. Our study aims to understand the impact of five popular LOD accommodation approaches on mixture analysis results with multiple exposures subject to LOD, including omitting subjects with any exposures below LOD (complete case analysis); single imputations by LOD/
methodsIn extensive simulation studies with high-dimensional and highly correlated exposures and a continuous health outcome, we examined the performance of each LOD approach on three mixture analysis methods: elastic net regression, weighted quantile sum regression (WQS) and Bayesian kernel machine regression (BKMR). We further analyzed data from the National Health and Nutrition Examination Survey (NHANES) on how persistent organic pollutants (POPs) influenced leukocyte telomere length (LTL).
resultsComplete case analysis was inefficient and could result in severe bias for some mixture methods. Imputation by LOD/
conclusionsOur study favored using truncated MI and censored AFT models to accommodate values below LOD for the stability of downstream mixture analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.