Evidence map›Paper›PMID 38756804›Full record

ArticleChemical science2024

Enantioselective copper-catalyzed B-H bond insertion reaction of α-diazo phosphonates to access chiral α-boryl phosphonates.

Longlong Li, Kui Yu, Hejun An, Xinping Cai, Qiuling Song

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Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Longlong LiKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry and College of Materials Science at Fuzhou University Fuzhou Fujian 350108 China qsong@fzu.edu.cn.
Kui YuKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry and College of Materials Science at Fuzhou University Fuzhou Fujian 350108 China qsong@fzu.edu.cn.
Hejun AnKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry and College of Materials Science at Fuzhou University Fuzhou Fujian 350108 China qsong@fzu.edu.cn.
Xinping CaiKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry and College of Materials Science at Fuzhou University Fuzhou Fujian 350108 China qsong@fzu.edu.cn.
Qiuling SongKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry and College of Materials Science at Fuzhou University Fuzhou Fujian 350108 China qsong@fzu.edu.cn.ORCID https://orcid.org/0000-0002-9836-8860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chiral phosphorus-containing compounds find applications across various fields, including asymmetric catalysis, medicinal chemistry, and materials science. Despite the abundance of reported highly enantioselective methods for synthesizing various chiral phosphorus compounds, the enantioselective synthesis of α-boryl phosphorus compounds still remains an unknown territory. Here, we report a method for the construction of chiral α-boryl phosphates by asymmetric B-H insertion reaction using α-diazo phosphates as carbene precursors, cheap and readily available copper salt as the catalyst and chiral oxazoline as the ligand. This method can directly afford a series of stable α-boryl phosphates with a yield up to 97% and an enantioselectivity up to 98% ee. The operating procedure of this method is straightforward, offering a broad substrate applicability, remarkable tolerance towards various functional groups, and gentle reaction conditions.

Identifiers

PMID38756804
PMCPMC11095379

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.