Evidence map›Paper›PMID 38758294›Full record

Trial reportDiabetes2024

Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes.

Liana K Billings, Kathleen A Jablonski, Qing Pan, Jose C Florez, Paul W Franks, Ronald B Goldberg, Marie-France Hivert, Steven E Kahn, William C Knowler, Christine G Lee and 8 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. The Clock is Still Ticking: Tirzepatide and the Myth of Halting the Natural History of Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Liana K BillingsDivision of Endocrinology, Department of Medicine, NorthShore University HealthSystem/Endeavor Health, Skokie, IL.ORCID 0000-0001-7991-3010
Kathleen A JablonskiBiostatistics Center, George Washington University, Washington, DC.
Qing PanBiostatistics Center, George Washington University, Washington, DC.ORCID 0000-0003-1253-0490
Jose C FlorezDiabetes Unit, Massachusetts General Hospital, Boston, MA.
Paul W FranksGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Science, Lund University, Skåne University Hospital, Malmö, Sweden.
Ronald B GoldbergLeonard M. Miller School of Medicine, University of Miami, Miami, FL.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA.
Steven E KahnDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle.
William C KnowlerNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ.
Christine G LeeDivision of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Jordi MerinoDiabetes Unit, Massachusetts General Hospital, Boston, MA.
Alicia Huerta-ChagoyaCenter for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Josep M MercaderDiabetes Unit, Massachusetts General Hospital, Boston, MA.
Sridharan RaghavanDepartment of Veterans Affairs Eastern Colorado Health Care System, Aurora, CO.
Zhuqing ShiProgram for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL.
Shylaja SrinivasanDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA.
Jianfeng XuProgram for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL.
Miriam S UdlerDiabetes Unit, Massachusetts General Hospital, Boston, MA.ORCID 0000-0003-3824-9162

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · GEORGE WASHINGTON UNIVERSITY · 1994 to 2005
$23.7M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · 1986 to 2025
$12.6M
Clinical Center for NIH's Nutrition for Precision Health: The All Of Us New England Research CollaborativeUG1HD107691 · NICHD · TUFTS UNIVERSITY BOSTON · 2023 to 2025
$7.2M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · MASSACHUSETTS GENERAL HOSPITAL · 1994 to 2025
$6.0M
Post-DDP Follow-up StudyU01DK048413 · UNIVERSITY OF WASHINGTON · 1994 to 2005
$4.4M
TITLE OMITTEDU01DK048349 · YESHIVA UNIVERSITY · 1994 to 2005
$4.0M
PRIMARY PREVENTION TRIALU01DK048443 · UNIVERSITY OF SOUTHERN CALIFORNIA · 1994 to 2005
$4.0M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048397 · MASSACHUSETTS GENERAL HOSPITAL · 1994 to 2005
$3.8M
Post-DPP Follow-up StudyU01DK048485 · JOHNS HOPKINS UNIVERSITY · 1994 to 2005
$3.7M
NIDDM PRIMARY PREVENTION TRIALU01DK048412 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1994 to 2005
$3.6M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048339 · UNIVERSITY OF CALIFORNIA SAN DIEGO · 1994 to 2005
$3.6M
Post-DPP Follow-Up StudyU01DK048400 · WASHINGTON UNIVERSITY · 1994 to 2005
$3.6M
American Diabetes Association 7-21-JDFM-005Boettcher Foundation Webb Waring Biomedical Research AwardCSRD VA IK2 CX001907NHGRI NIH HHS U01 HG011723NHLBI NIH HHS K24 HL157960NICHD NIH HHS UG1 HD107691NIDDK NIH HHS K23 DK114551NIDDK NIH HHS K23DK114551NIDDK NIH HHS L30 DK106874NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK072041NIDDK NIH HHS T32 DK007161NIDDK NIH HHS U01 DK048339NIDDK NIH HHS U01 DK048349NIDDK NIH HHS U01 DK048375NIDDK NIH HHS U01 DK048377NIDDK NIH HHS U01 DK048380NIDDK NIH HHS U01 DK048381NIDDK NIH HHS U01 DK048387NIDDK NIH HHS U01 DK048397NIDDK NIH HHS U01 DK048400NIDDK NIH HHS U01 DK048404NIDDK NIH HHS U01 DK048406NIDDK NIH HHS U01 DK048407NIDDK NIH HHS U01 DK048411NIDDK NIH HHS U01 DK048412NIDDK NIH HHS U01 DK048413NIDDK NIH HHS U01 DK048434NIDDK NIH HHS U01 DK048437NIDDK NIH HHS U01 DK048443NIDDK NIH HHS U01 DK048468NIDDK NIH HHS U01 DK048485NIDDK NIH HHS U01 DK048489NIDDK NIH HHS U01 DK048514NIH HHS UG1 HD107691NorthShore University HealthSystem NorthShore Auxiliary Scholars AwardUS Department of Veterans Affairs IK2-CX001907
6 · The paper itself

Abstract

Partitioned polygenic scores (pPS) have been developed to capture pathophysiologic processes underlying type 2 diabetes (T2D). We investigated the association of T2D pPS with diabetes-related traits and T2D incidence in the Diabetes Prevention Program. We generated five T2D pPS (β-cell, proinsulin, liver/lipid, obesity, lipodystrophy) in 2,647 participants randomized to intensive lifestyle, metformin, or placebo arms. Associations were tested with general linear models and Cox regression with adjustment for age, sex, and principal components. Sensitivity analyses included adjustment for BMI. Higher β-cell pPS was associated with lower insulinogenic index and corrected insulin response at 1-year follow-up with adjustment for baseline measures (effect per pPS SD -0.04, P = 9.6 × 10-7, and -8.45 μU/mg, P = 5.6 × 10-6, respectively) and with increased diabetes incidence with adjustment for BMI at nominal significance (hazard ratio 1.10 per SD, P = 0.035). The liver/lipid pPS was associated with reduced 1-year baseline-adjusted triglyceride levels (effect per SD -4.37, P = 0.001). There was no significant interaction between T2D pPS and randomized groups. The remaining pPS were associated with baseline measures only. We conclude that despite interventions for diabetes prevention, participants with a high genetic burden of the β-cell cluster pPS had worsening in measures of β-cell function. ARTICLE HIGHLIGHTS:

Indexed as

Diabetes Mellitus, Type 2Insulin-Secreting CellsPrediabetic StateAdultFemaleGenetic Predisposition to DiseaseHumansIncidenceMaleMiddle AgedMultifactorial Inheritance

Identifiers

PMID38758294
PMCPMC11262049

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.