Evidence mapPaperPMID 38758481Full record

ArticleProbiotics and antimicrobial proteins2025

Probiotic Pediococcus acidilactici Strains Exert Anti-inflammatory Effects by Regulating Intracellular Signaling Pathways in LPS-Induced RAW 264.7 Cells.

Im-Kyung Woo, Jun-Hyun Hyun, Hye Ji Jang, Na-Kyoung Lee, Hyun-Dong Paik

Abstract read
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Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Journal of microbiology and biotechnology · 2026
    Article
  3. Phytosynbiotic Containing Double-Layer MicroencapsulatedAnimals : an open access journal from MDPI · 2026
    Article
  4. Lactose-Free Fermented Milk Production UsingJournal of microbiology and biotechnology · 2026
    Article
  5. Article
  6. Immunomodulatory Properties and Ameliorative Effects ofJournal of microbiology and biotechnology · 2025
    Article
  7. Article
  8. Apple Juice Fermented withFoods (Basel, Switzerland) · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Im-Kyung WooDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Jun-Hyun HyunDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Hye Ji JangDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Na-Kyoung LeeDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Hyun-Dong PaikDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea. hdpaik@konkuk.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the anti-inflammatory effects of Pediococcus acidilactici strains isolated from fermented vegetables on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. In addition, the probiotic characteristics and safety were evaluated. Our results show that Ped. acidilactici strains possess high survivability in simulated gastrointestinal environments and strong attachment to HT-29 cells. All Ped. acidilactici strains exhibited γ-hemolysis and resistance to gentamicin, kanamycin, and streptomycin, a characteristic commonly observed in lactic acid bacteria. Treatment with Ped. acidilactici inhibited the expression of inducible nitric oxide synthase and cyclooxygenase-2, leading to a subsequent reduction in nitric oxide and prostaglandin E

Indexed as

Anti-Inflammatory AgentsMacrophagesPediococcus acidilacticiProbioticsAnimalsCyclooxygenase 2DinoprostoneHT29 CellsHumansInterleukin-1betaInterleukin-6LipopolysaccharidesMiceNF-kappa BNitric OxideNitric Oxide Synthase Type IIAnti-Inflammatory AgentsCyclooxygenase 2DinoprostoneInterleukin-1betaInterleukin-6LipopolysaccharidesNF-kappa BNitric OxideNitric Oxide Synthase Type IIAnti-inflammatoryMitogen-activated protein kinaseNuclear factor-κBPediococcus acidilacticiProbiotics

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.