Evidence map›Paper›PMID 38758792›Full record

ArticleScience advances2024

KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3.

Yongqing Liu, Minghua Fan, Junhua Yang, Ljubica Mihaljević, Kevin Hong Chen, Yingzhi Ye, Shuying Sun, Zhaozhu Qiu

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  12. Review
  13. Review
  14. Acetyltransferase in cardiovascular disease and aging.The journal of cardiovascular aging · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongqing LiuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0001-4160-1457
Minghua FanSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Junhua YangDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ljubica MihaljevićDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kevin Hong ChenDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5421-1538
Yingzhi YeDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7380-6529
Shuying SunDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-8449-7370
Zhaozhu QiuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9122-6077

Funding

Single molecule study of C9ORF72 repeat RNA metabolisms in ALS/FTDRF1NS113820 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING, WU, BIN · 2020 to 2025
$6.2M
Molecular Identity and Physiological Function of Novel Chloride ChannelsR35GM124824 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Zhaozhu Qiu · 2017 to 2026
$4.8M
Regulation mechanism and functional genomics of LINE1 RNA in TDP-43 linked neurodegenerationR01AG078948 · NIA · JOHNS HOPKINS UNIVERSITY · PI Xianjun Dong, Shuying Sun · 2022 to 2026
$4.2M
Validation of a new large-pore channel as a novel target for neuropathic painRF1NS134549 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Yun Guan, Zhaozhu Qiu · 2023 to 2026
$3.4M
Cell Swelling-Activated Chloride Channel in Ischemic StrokeR01NS118014 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QIU, ZHAOZHU · 2020 to 2024
$2.6M
The role of m6A RNA methylation in C9ORF72-ALS/FTDRF1NS127925 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2022 to 2024
$2.0M
American Heart Association-American Stroke Association 20POST35200185 - JUNHUA YANGAmerican Heart Association-American Stroke Association 857671NIA NIH HHS R01 AG078948NIGMS NIH HHS R35 GM124824NINDS NIH HHS R01 NS118014NINDS NIH HHS RF1 NS113820NINDS NIH HHS RF1 NS127925NINDS NIH HHS RF1 NS134549
6 · The paper itself

Abstract

Intellectual disability (ID) affects ~2% of the population and ID-associated genes are enriched for epigenetic factors, including those encoding the largest family of histone lysine acetyltransferases (KAT5-KAT8). Among them is

Indexed as

CognitionHistone AcetyltransferasesThrombospondinsWnt Signaling PathwayAnimalsCA3 Region, HippocampalMiceMice, KnockoutNeuronal PlasticityR-SpondinsHistone AcetyltransferasesKAT6A protein, mouseRSPO2 protein, mouseR-SpondinsThrombospondins

Identifiers

PMID38758792
PMCPMC11100567

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.