Evidence map›Paper›PMID 38761981›Full record

ArticleSLAS discovery : advancing life sciences R & D2024

A high-throughput response to the SARS-CoV-2 pandemic.

Lynn Rasmussen, Shalisa Sanders, Melinda Sosa, Sara McKellip, N Miranda Nebane, Yohanka Martinez-Gzegozewska, Andrew Reece, Pedro Ruiz, Anna Manuvakhova, Ling Zhai and 5 more

Abstract read
In one paragraph

Article in SLAS discovery : advancing life sciences R & D, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Rapid luminescence-based screening method for SARS- CoV-2 inhibitors discovery.SLAS discovery : advancing life sciences R & D · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lynn RasmussenSouthern Research, Birmingham, AL, USA.
Shalisa SandersSouthern Research, Birmingham, AL, USA.
Melinda SosaSouthern Research, Birmingham, AL, USA.
Sara McKellipSouthern Research, Birmingham, AL, USA.
N Miranda NebaneSouthern Research, Birmingham, AL, USA.
Yohanka Martinez-GzegozewskaSouthern Research, Birmingham, AL, USA.
Andrew ReeceSouthern Research, Birmingham, AL, USA.
Pedro RuizSouthern Research, Birmingham, AL, USA.
Anna ManuvakhovaSouthern Research, Birmingham, AL, USA.
Ling ZhaiSouthern Research, Birmingham, AL, USA.
Brooke WarrenSouthern Research, Birmingham, AL, USA.
Aliyah CurrySouthern Research, Birmingham, AL, USA.
Qinghua ZengSouthern Research, Birmingham, AL, USA.
J Robert BostwickSouthern Research, Birmingham, AL, USA.
Paige N VinsonSouthern Research, Birmingham, AL, USA. Electronic address: pvinson@southernresearch.org.

Funding

Project 4 - Influenza - UABU19AI142759 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WHITLEY, RICHARD J. · 2019 to 2023
$37.5M
Construction/SEBLAB/Regional Biocontainment LaboratoryUC6AI058599 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARCHASE, RICHARD BANFIELD · 2003 to 2006
$22.0M
Facility Management, Maintenance and Operations CoreUC7AI180255 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Sixto Manuel Leal · 2023 to 2026
$13.3M
Upgrade and operational improvements to the SouthEastern Biosafety Laboratory, Alabama, Birmingham (SEBLAB)G20AI167409 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEAL, SIXTO MANUEL · 2021 to 2022
$7.7M
NIAID NIH HHS G20 AI167409NIAID NIH HHS U19 AI142759NIAID NIH HHS UC6 AI058599NIAID NIH HHS UC7 AI180255
6 · The paper itself

Abstract

Four years after the beginning of the COVID-19 pandemic, it is important to reflect on the events that have occurred during that time and the knowledge that has been gained. The response to the pandemic was rapid and highly resourced; it was also built upon a foundation of decades of federally funded basic and applied research. Laboratories in government, pharmaceutical, academic, and non-profit institutions all played roles in advancing pre-2020 discoveries to produce clinical treatments. This perspective provides a summary of how the development of high-throughput screening methods in a biosafety level 3 (BSL-3) environment at Southern Research Institute (SR) contributed to pandemic response efforts. The challenges encountered are described, including those of a technical nature as well as those of working under the pressures of an unpredictable virus and pandemic.

Indexed as

COVID-19High-Throughput Screening AssaysPandemicsSARS-CoV-2Antiviral AgentsHumansAntiviral AgentsAntiviralBSL-3CoronavirusCOVIDCOVID-19Drug discoveryHigh-throughputHTSMERSPandemicSARSSARS2SARS-CoVSARS-CoV-2

Identifiers

PMID38761981
PMCPMC12182970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.