Evidence map›Paper›PMID 38761995›Full record

ReviewThe Journal of allergy and clinical immunology2024

T

Alyssa E James, Manar Abdalgani, Paneez Khoury, Alexandra F Freeman, Joshua D Milner

Abstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Italian pediatric experts' consensus statement on diagnosis and management of primary atopic disorders.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Guideline
  2. Emerging Paediatric Uses of Dupilumab Beyond Approvals.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  3. Incidence of autoimmune diseases in children with atopy treated with dupilumab.The Journal of allergy and clinical immunology · 2026
    Article
  4. Expanding the scope of human immunology in theJournal of human immunity · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. The genetics of hyper IgE syndromes.Frontiers in immunology · 2025
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alyssa E JamesNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Manar AbdalganiColumbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.
Paneez KhouryNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Alexandra F FreemanNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: freemaal@mail.nih.gov.
Joshua D MilnerColumbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.

Funding

Allergy and Immunology Clinical Fellowship Program SupportZIEAI001148 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KHOURY, PANEEZ · 2011 to 2025
$10.9M
Intramural NIH HHS ZIE AI001148
6 · The paper itself

Abstract

Monogenic lesions in pathways critical for effector functions responsible for immune surveillance, protection against autoinflammation, and appropriate responses to allergens and microorganisms underlie the pathophysiology of inborn errors of immunity (IEI). Variants in cytokine production, cytokine signaling, epithelial barrier function, antigen presentation, receptor signaling, and cellular processes and metabolism can drive autoimmunity, immunodeficiency, and/or allergic inflammation. Identification of these variants has improved our understanding of the role that many of these proteins play in skewing toward T

Indexed as

Th2 CellsAnimalsCytokinesHumansHypersensitivityCytokinesallergic inflammationasthmaatopic dermatitisatopydysregulationeosinophiliaimmunomodulationInborn errors of immunitymast cell dysregulationprimary atopic disordersprimary immunodeficiency

Identifiers

PMID38761995
PMCPMC12295673

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.