ArticleCardiovascular diabetology2024
Association of triglyceride glucose index and triglyceride glucose-body mass index with sudden cardiac arrest in the general population.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies.Cardiovascular diabetology · 2025Pooled it
- Joint longitudinal trajectories of the triglyceride-glucose index combined with BMI and waist-to-height ratio and incident cardiovascular disease: a prospective cohort study from the English longitudinal study of ageing.Cardiovascular diabetology · 2026Article
- Comparative prognostic value of TyG index and TyG-BMI for 90-day all-cause mortality in critically ill older adults with ASCVD: a machine learning analysis of the MIMIC-IV database.Cardiovascular diabetology · 2026Article
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- Insulin resistance, vitamin D status, and cardiovascular risk in a general population cohort.Frontiers in nutrition · 2026Article
- Association Between the Triglyceride-Glucose Index and Clinical Outcomes Modified by Diabetes Duration in Patients with Acute Coronary Syndrome and Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association of triglyceride-glucose and obesity-derived indices with the risk of aortic stenosis among individuals in cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2026Article
- Editorial: Interplay between glucose and lipid homeostasis in metabolic health.Frontiers in endocrinology · 2026Article
- Higher Dietary Insulinemic Potential, and Triglyceride-Glucose (TyG)-BMI Index may Contribute to Coronary Artery Disease Severity: a Cross-Sectional Study.Journal of epidemiology and global health · 2025Article
- Evaluation of four insulin resistance surrogate indicators for predicting short-term mortality in critically ill patients with ischemic stroke: a nationwide retrospective cohort study.Cardiovascular diabetology · 2025Article
- The association between triglyceride glucose-body mass index and mortality in intensive care unit patients: a propensity score matching analysis.European journal of medical research · 2025Article
- Interaction between triglyceride-glucose-body mass index and age in coronary artery stenosis severity: a sex-stratified exploratory analysis.BMC cardiovascular disorders · 2025Article
- The Interplay of Cardiometabolic Syndrome Phenotypes and Cardiovascular Risk Indices in Patients Diagnosed with Diabetes Mellitus.International journal of molecular sciences · 2025Article
- Association between triglyceride glucose body mass index and 1 year all cause mortality in stage 4 CKM syndrome patients.Scientific reports · 2025Article
- Nonlinear relationships between the triglyceride glucose-body mass index and cardiovascular disease in middle-aged and elderly women from NHANES (1999-2018).Scientific reports · 2025Article
- Triglyceride-glucose index correlates with the incidences and prognoses of cardiac arrest following acute myocardial infarction: data from two large-scale cohorts.Cardiovascular diabetology · 2025Article
- Insights into the complex relationship between triglyceride glucose-waist height ratio index, mean arterial pressure, and cardiovascular disease: a nationwide prospective cohort study.Cardiovascular diabetology · 2025Article
- The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Evaluation of the effects of short-term PMBMC cardiovascular disorders · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundInsulin resistance (IR) significantly contributes to cardiovascular disease (CVD) development. Triglyceride glucose (TyG) index and triglyceride glucose-body mass index (TyG-BMI) are recognised as convenient proxies for IR. However, their relationship with sudden cardiac arrest (SCA) remains unclear.
methodsThis prospective cohort analysis included 355,242 UK Biobank participants with available TyG index and TyG-BMI data and no history of CVD. Cox proportional risk models assessed the association between the TyG index, TyG-BMI and SCA risk. Additionally, Accelerated Failure Time (AFT) models were employed to investigate the timing of SCA onset. The impact of dynamic increases in TyG index and TyG-BMI levels on SCA risk was examined using restricted cubic spline.
resultsOver a median follow-up period of 165.4 months (interquartile range 156.5-174 months), 1,622 cases of SCA were recorded. Multivariate Cox regression analysis revealed a 9% increase in SCA risk per standard deviation increase in TyG index (adjusted hazard ratio (aHR) = 1.09, 95% confidence interval (CI) 1.04-1.15) and an 14% increase per standard deviation increase in TyG-BMI (aHR 1.14, 95% CI 1.09-1.2). AFT models indicated earlier median times to SCA occurrence with increasing quintiles of TyG index and TyG-BMI compared to the lowest quintile (P for trend < 0.05). SCA risk was linearly (P = 0.54) and non-linearly (P = 0.007) correlated with gradual increases in TyG index and TyG-BMI levels, respectively. Sex-stratified analyses showed stronger associations in women.
conclusionsHigher TyG index and TyG-BMI levels are associated with an increased SCA risk and earlier onset, particularly in women.
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