ArticleWorld journal of gastrointestinal oncology2024
Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer.
Article in World journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAs the primary microtubule organizing center in animal cells, centrosome abnormalities are involved in human colon cancer.
aimTo explore the role of centrosome-related genes (CRGs) in colon cancer.
methodsCRGs were collected from public databases. Consensus clustering analysis was performed to separate the Cancer Genome Atlas cohort. Univariate Cox and least absolute shrinkage selection operator regression analyses were performed to identify candidate prognostic CRGs and construct a centrosome-related signature (CRS) to score colon cancer patients. A nomogram was developed to evaluate the CRS risk in colon cancer patients. An integrated bioinformatics analysis was conducted to explore the correlation between the CRS and tumor immune microenvironment and response to immunotherapy, chemotherapy, and targeted therapy. Single-cell transcriptome analysis was conducted to examine the immune cell landscape of core prognostic genes.
resultsA total of 726 CRGs were collected from public databases. A CRS was constructed, which consisted of the following four genes:
conclusionWe constructed a centrosome-related prognostic signature that can accurately predict the prognosis of colon cancer patients, contributing to the development of individualized treatment for colon cancer.
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