Evidence map›Paper›PMID 38766259›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample.

Yousef Khan, Christal N Davis, Zeal Jinwala, Kyra L Feuer, Sylvanus Toikumo, Emily E Hartwell, Sandra Sanchez-Roige, Roseann E Peterson, Alexander S Hatoum, Henry R Kranzler and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yousef KhanDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0009-0002-3093-3947
Christal N DavisDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0000-0003-3974-5598
Zeal JinwalaDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0009-0005-5062-0827
Kyra L FeuerDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0000-0003-3704-6136
Sylvanus ToikumoDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0000-0002-6024-0693
Emily E HartwellDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0000-0002-5137-9714
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, United States.ORCID 0000-0001-6137-5699
Roseann E PetersonInstitute for Department of Psychiatry and Behavioral Sciences, Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, United States.ORCID 0000-0001-6402-849X
Alexander S HatoumDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, United States.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0000-0002-1018-0450
Rachel L KemberDepartment of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.ORCID 0000-0001-8820-2659

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2014 to 2026
$19.6M
Cross-Population Working Group on Genes and Environment in Major Depression (POP-GEM): Advancing the Understating of Etiology through DiversityR01MH125938 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Roseann Elizabeth Peterson · 2022 to 2026
$4.2M
Postdoctoral Training Program in Genomic MedicineT32HG009495 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Katherine L. Nathanson, Bogdan Pasaniuc · 2017 to 2026
$4.2M
Characterizing the phenotypic spectrum associated with genetic liability for alcohol use disorderK01AA028292 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI KEMBER, RACHEL LORRAINE · 2021 to 2024
$505k
Genetic Vulnerability for Sustained Multi-Substance Use in MVPI01BX003341 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI FEDERMAN, DANIEL, JUSTICE, AMY CAROLINE · 2017 to 2017
–
Genetic architecture of substance use disorders and major depressionIK2CX002336 · VA · PHILADELPHIA VA MEDICAL CENTER · PI Emily Hartwell · 2022 to 2026
–
BLRD VA I01 BX003341CSRD VA IK2 CX002336NCATS NIH HHS UL1 TR001878NHGRI NIH HHS T32 HG009495NIAAA NIH HHS K01 AA028292NIAAA NIH HHS P50 AA022537NIMH NIH HHS R01 MH125938
6 · The paper itself

Abstract

The etiology of substance use disorders (SUDs) and psychiatric disorders reflects a combination of both transdiagnostic (i.e., common) and disorder-level (i.e., independent) genetic risk factors. We applied genomic structural equation modeling to examine these genetic factors across SUDs, psychotic, mood, and anxiety disorders using genome-wide association studies (GWAS) of European- (EUR) and African-ancestry (AFR) individuals. In EUR individuals, transdiagnostic genetic factors represented SUDs (143 lead single nucleotide polymorphisms [SNPs]), psychotic (162 lead SNPs), and mood/anxiety disorders (112 lead SNPs). We identified two novel SNPs for mood/anxiety disorders that have probable regulatory roles on

Identifiers

PMID38766259
PMCPMC11100926

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.