Evidence map›Paper›PMID 38767439›Full record

ArticleKorean circulation journal2024

Sex-Specific Susceptibility Loci Associated With Coronary Artery Aneurysms in Patients With Kawasaki Disease.

Jae-Jung Kim, Young Mi Hong, Sin Weon Yun, Kyung-Yil Lee, Kyung Lim Yoon, Myung-Ki Han, Gi Beom Kim, Hong-Ryang Kil, Min Seob Song, Hyoung Doo Lee and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean circulation journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jae-Jung KimAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-7406-3261
Young Mi HongDepartment of Pediatrics, Ewha Womans University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-6600-7876
Sin Weon YunDepartment of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-8947-703X
Kyung-Yil LeeDepartment of Pediatrics, Daejeon St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-6510-1580
Kyung Lim YoonDepartment of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea.ORCID https://orcid.org/0000-0003-4734-900X
Myung-Ki HanDepartment of Pediatrics, Gangneung Asan Hospital, University of Ulsan, Gangneung, Korea.ORCID https://orcid.org/0000-0003-1817-8088
Gi Beom KimDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-7880-280X
Hong-Ryang KilDepartment of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.ORCID https://orcid.org/0000-0003-4925-8240
Min Seob SongDepartment of Pediatrics, Inje University Paik Hospital, Busan, Korea.ORCID https://orcid.org/0000-0003-3426-6803
Hyoung Doo LeeDepartment of Pediatrics, Pusan National University Hospital, Busan, Korea.ORCID https://orcid.org/0000-0002-6125-187X
Kee Soo HaDepartment of Pediatrics, Korea University Guro Hospital, Guro, Korea.ORCID https://orcid.org/0000-0001-6753-5411
Hyun Ok JunDepartment of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2270-0123
Jeong Jin Yu *Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1601-3685
Gi Young Jang *Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea.ORCID https://orcid.org/0000-0002-4831-1188
Jong-Keuk Lee *Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. cookie_jklee@hotmail.com.ORCID https://orcid.org/0000-0003-1125-4017
Korean Kawasaki Disease Genetics Consortium

Funding

Asan Institute for Life Sciences, Asan Medical Center 2022IL0008National Research Foundation of Korea 2021R1F1A1057151
6 · The paper itself

Abstract

BACKGROUND AND

objectivesKawasaki disease (KD) is an acute vasculitis that primarily affects children under age 5 years. Approximately 20-25% of untreated children with KD and 3-5% of those treated with intravenous immunoglobulin therapy develop coronary artery aneurysms (CAAs). The prevalence of CAAs is much higher in male than in female patients with KD, but the underlying factors contributing to susceptibility to CAAs in patients with KD remain unclear. This study aimed to identify sex-specific susceptibility loci associated with CAAs in KD patients.

methodsA sex-stratified genome-wide association study (GWAS) was performed using previously obtained GWAS data from 296 KD patients and a new replication study in an independent set of 976 KD patients by comparing KD patients without CAA (controls) and KD patients with aneurysms (internal diameter ≥5 mm) (cases).

resultsSix male-specific susceptibility loci,

conclusionsA sex-stratified GWAS identified 6 male-specific (

Indexed as

Coronary aneurysmGenome-wide association studyMucocutaneous lymph node syndromeSex

Identifiers

PMID38767439
PMCPMC11361772

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.