Evidence map›Paper›PMID 38768397›Full record

ReviewAnnual review of biomedical data science2024

Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine.

Yonghyun Nam, Jaesik Kim, Sang-Hyuk Jung, Jakob Woerner, Erica H Suh, Dong-Gi Lee, Manu Shivakumar, Matthew E Lee, Dokyoon Kim

Abstract readReview
In one paragraph

Review in Annual review of biomedical data science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. AI-driven drug design: a comprehensive review.Journal of computer-aided molecular design · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Observational
  15. Review
  16. Review
  17. Article
  18. ChatGPT in precision medicine.APL bioengineering · 2026
    Review
  19. Review
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yonghyun NamDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: dokyoon.kim@pennmedicine.upenn.edu.
Jaesik KimInstitute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sang-Hyuk JungDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: dokyoon.kim@pennmedicine.upenn.edu.
Jakob WoernerDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: dokyoon.kim@pennmedicine.upenn.edu.
Erica H SuhDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: dokyoon.kim@pennmedicine.upenn.edu.
Dong-Gi LeeDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: dokyoon.kim@pennmedicine.upenn.edu.
Manu ShivakumarDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: dokyoon.kim@pennmedicine.upenn.edu.
Matthew E LeeDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: dokyoon.kim@pennmedicine.upenn.edu.
Dokyoon KimInstitute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Translational big data analytic approaches to advance drug repurposing for Alzheimer's diseaseR01AG071470 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON, NING, XIA · 2021 to 2025
$3.8M
Methods for Enhancing Polygenic Risk Prediction Models for Complex DiseaseR01HL169458 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Dokyoon Kim, MARYLYN D RITCHIE · 2023 to 2026
$3.1M
Unravelling genetic basis of comorbidity using EHR-linked biobank dataR01GM138597 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON · 2020 to 2023
$2.2M
NHLBI NIH HHS R01 HL169458NIA NIH HHS R01 AG071470NIGMS NIH HHS R01 GM138597
6 · The paper itself

Abstract

The integration of multiomics data with detailed phenotypic insights from electronic health records marks a paradigm shift in biomedical research, offering unparalleled holistic views into health and disease pathways. This review delineates the current landscape of multimodal omics data integration, emphasizing its transformative potential in generating a comprehensive understanding of complex biological systems. We explore robust methodologies for data integration, ranging from concatenation-based to transformation-based and network-based strategies, designed to harness the intricate nuances of diverse data types. Our discussion extends from incorporating large-scale population biobanks to dissecting high-dimensional omics layers at the single-cell level. The review underscores the emerging role of large language models in artificial intelligence, anticipating their influence as a near-future pivot in data integration approaches. Highlighting both achievements and hurdles, we advocate for a concerted effort toward sophisticated integration models, fortifying the foundation for groundbreaking discoveries in precision medicine.

Indexed as

Artificial IntelligenceData AnalysisMultiomicsPrecision MedicineMachine LearningSingle-Cell Analysisbiobankimaging phenotypeslongitudinal analysismachine learningmultimodal data integrationmultiomics data integrationprecision medicinerisk assessmentsingle-cell omics

Identifiers

PMID38768397
PMCPMC11972123

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.