SynthesisJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2025
Difference in coagulation systems of large animal species used in cardiovascular research: a systematic review.
Synthesis in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Guideline
- Prolonged Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation in Sheep.Annals of biomedical engineering · 2026Article
- Standardization ofPerfusion · 2026Review
- Standardization of In Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development.Artificial organs · 2026Review
- Evaluation of a point-of-care device for creatinine measurement in nonazotemic pigs presented to a referral hospital.American journal of veterinary research · 2026Article
- Large Animal Models for Preclinical Evaluation of Heart Valve Prostheses, Left Ventricular Assist Devices and Total Artificial Hearts: A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development.Interdisciplinary cardiovascular and thoracic surgery · 2026Review
- In Vivo Evaluation of a Novel Long-Term Intravascular Implantable Continuous Blood Glucose Monitor in an Ovine Model: A Glucotrack Inc. Investigation.Journal of diabetes research · 2026Article
- Idiopathic Intracranial Hypertension Animal Models and Venous Sinus Stenting: Status of Disease and Device-Focused Evidence.Brain sciences · 2025Review
- Genomic architecture of purebred and crossbred Moghani lambs with Texel and Booroola sheep.Scientific reports · 2025Article
- Escalating doses of intravenous APAC demonstrate antithrombotic effect in pigs.Thrombosis journal · 2025Article
- Breaking the one-dimensional paradigm: why cardiovascular research needs a multi-systems revolution.Frontiers in physiology · 2025Article
- Hypoxia Preconditioned Serum Hydrogel (HPS-H) Accelerates Dermal Regeneration in a Porcine Wound Model.Gels (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preclinical testing using animal models is indispensable in cardiovascular research. However, the translation to clinical practice of these animal models is questionable since it is not always clear how representative they are. This systematic review intends to summarize the interspecies differences in the coagulation profile of animal models used in cardiovascular research. It aims to guide future research in choosing the optimal animal species. A literature search of PubMed, Embase, Web of Science (Core Collection) and Cochrane Library was performed using a search string that was well defined and not modified during the study. An overview of the search terms used in each database can be found in the appendix. Articles describing coagulation systems in large animals were included. We identified 30 eligible studies of which 15 were included. Compared to humans, sheep demonstrated a less active external pathway of coagulation. Sheep had a higher platelet count but the platelet activatability and response to biomaterials were lower. Both sheep and pigs displayed no big differences in the internal coagulation system compared to humans. Pigs showed results very similar to those of humans, with the exception of a higher platelet count and stronger platelet aggregation in pigs. Coagulation profiles of different species used for preclinical testing show strong variation. Adequate knowledge of these differences is key in the selection of the appropriate species for preclinical cardiovascular research. Future thrombogenicity research should compare sheep to pig in an identical experimental setup.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.